Indian journal of Medical Biochemistry

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VOLUME 21 , ISSUE 1 ( January-June, 2017 ) > List of Articles

ORIGINAL ARTICLE

Thyroid Function Status in Indian Adult Nonpregnant Females in Ranchi, India

Nandita Hazra, Sarvinder Singh, Binay Mitra, Bhaskar Shahbabu

Citation Information : Hazra N, Singh S, Mitra B, Shahbabu B. Thyroid Function Status in Indian Adult Nonpregnant Females in Ranchi, India. Indian J Med Biochem 2017; 21 (1):25-29.

DOI: 10.5005/jp-journals-10054-0014

License: CC BY 3.0

Published Online: 01-06-2017

Copyright Statement:  Copyright © 2017; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim

Thyroid disorders are one of the most common endocrine diseases in India. Thyroid disorders are more common in women than in men and contribute to significant morbidity. In this postiodization era, there is paucity of pan-Indian data of thyroid disorder status among adult nonpregnant women. This study was done to analyze the thyroid hormone levels in women of Jharkhand region, which is traditionally known to be an iodine-deficient area.

Materials and methods

Three hundred and forty nonpregnant adult females in Ranchi area who were consuming iodized salt formed part of the study group. Clinical evaluation was done by a gynecologist pertaining to thyroid illness. Thyroid function tests encompassing triiodothyronine, thyroxine, and thyroid-stimulating hormone were carried out by quantitative enzyme immunoassay method. Thyroid status of the population was defined as per kit reference range.

Results

Subjects with age range 20 to 67 years were divided into three groups as per clinical status of thyroid disorder, viz. total, disease free, and control. A total of 19.6% had biochemical evidence of thyroid disorder and 82.4% were euthyroid as per reference ranges in kit literature. Out of hypothyroid subjects, 3.2% had clinical and 14.4% had subclinical hypothyroidism. In the study group, no subjects were detected to have overt or subclinical hyperthyroidism. Multiple comparison analysis was done with Statistical Package for the Social Sciences version 20.0, a statistical software package.

Discussion

This is the first study in Jharkhand area on nonpregnant adult female population that are getting iodine sufficient foods in an iodine-deficient region. The study showed high prevalence of thyroid disorders in the study group. Hypothyroidism, predominantly subclinical hypothyroidism, is prevalent among women in this region.

How to cite this article

Chakrabarty BK, Mitra B, Shahbabu B, Hazra N, Singh S. Thyroid Function Status in Indian Adult Nonpregnant Females in Ranchi, India. Indian J Med Biochem 2017;21(1):25-29.


  1. Thyroid disorders in India: an epidemiological perspective. Indian J Endocrinol Metab 2011 Jul;15(Suppl 2):S78–S81.
  2. Prevalence of thyroid dysfunction among young females in a south Indian population. Indian J Endocrinol Metab 2015 Nov-Dec;19(6):781–784.
  3. Effects of increased iodine intake on thyroid disorders. Endocrinol Metab 2014 Sep;29(3):240–247.
  4. Thyroid disorders in women of Puducherry. Indian J Clin Biochem 2009 Jan;24(1):52–59.
  5. Female reproduction physiology adversely manipulated by thyroid disorders: a review of literature. Pak J Biol Sci 2013 Mar 1;16(3):112–120.
  6. Subclinical hypothyroidism and risk for incident myocardial infarction among postmenopausal women. J Clin Endocrinol Metab 2013 Jun;98(6):2308–2317.
  7. Evolution of iodine deficiency disorders control program in India: a journey of 5,000 years. Indian J Public Health 2013 Jul-Sep;57(3):126–132.
  8. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002 Feb;87(2):489–499.
  9. A radioimmunoassay of thyroxine. J Clin Endocrinol Metabol 1971 Nov;33(5):865–868.
  10. Evaluation of endocrine function. In: McPherson RA, Pincus MR, editors. Henry's clinical diagnosis and management by laboratory methods. 23rd ed. United States: Elsevier – Health Sciences Division; 2016 May 20. p. 373
  11. Iodine Status Worldwide, WHO Global Database on Iodine Deficiency. Geneva: Department of Nutrition for Health and Development, WHO 2004.
  12. Tracking progress toward elimination of iodine deficiency disorders in Jharkhand, India. Indian J Community Med 2008 Jul;33(3):182–185.
  13. Establishment of reference range for thyroid hormones in normal pregnant Indian women. BJOG 2008 Mar 7;115(5):602–606.
  14. Prevalence of thyroid disorders in patients visiting a tertiary care center in New Delhi: a three-year study. Asian J Med Sci 2012;3(4):15–23.
  15. Proportion of thyroid diseases in Jharkhand. Int J Pharm Sci Res 2016;(36):3843–3847.
  16. Prevalence of hypothyroidism in adults: an epidemiological study in eight cities of India. Indian J Endocrinol Metab 2013 Jul;17(4):647–652.
  17. The Colorado thyroid disease prevalence study. Arch Intern Med 2000 Feb 28;160(4):526–534.
  18. The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol 1977 Dec;7(6):481–493.
  19. Prevalence of thyroid disease, thyroid dysfunction and thyroid peroxidase antibodies in a large, unselected population. The health study of Nord-Trondelag (HUNT). Eur J Endocrinol 2000 Nov 1;143(5):639–647.
  20. Indicators for assessing iodine deficiency disorders and their control through salt iodization. Geneva: WHO/NUT/94.6; 1994.
  21. Thyroid cancer and thyroiditis in Salta, Argentina: a 40-yr study in relation to iodine prophylaxis. Endocr Pathol 2002 Fall;13(3):175–181.
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