Indian Journal of Medical Biochemistry

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VOLUME 21 , ISSUE 1 ( January-June, 2017 ) > List of Articles


Does Prolonged Storage of Serum Samples alter the Lab Results?

Devika Tayal, Mrinal Gupta

Citation Information : Tayal D, Gupta M. Does Prolonged Storage of Serum Samples alter the Lab Results?. Indian J Med Biochem 2017; 21 (1):30-33.

DOI: 10.5005/jp-journals-10054-0015

License: CC BY 3.0

Published Online: 01-12-2012

Copyright Statement:  Copyright © 2017; The Author(s).



Sample storage for prolonged periods can lead to alterations in routine biochemical parameters.


This study was undertaken to observe the biochemical changes on serum samples when they are stored for prolonged periods at –20°C on different routine biochemical parameters.


Significant changes were observed in serum glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, and potassium levels after 72 hours of storage, which further deteriorate in 3 months. Rest of the parameters did not show any significant alteration.


Prolonged storage of samples lead to alterations in the analyte concentration in serum. Serum glucose, AST, ALT, creatinine, and potassium levels should be estimated within 72 hours if prolonged storage is unavoidable. In conclusion, all the parameters should be assayed within 24 hours to avoid misinterpretation of results and better patient care.

How to cite this article

Tayal D, Gupta M, Goswami B. Does Prolonged Storage of Serum Samples alter the Lab Results? Indian J Med Biochem 2017;21(1):30-33.

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