Indian journal of Medical Biochemistry

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VOLUME 21 , ISSUE 1 ( January-June, 2017 ) > List of Articles

ORIGINAL ARTICLE

Status and Effect of Vitamin D on Microvascular Complication in Type II Diabetes Mellitus Patients

P Krushna Kishore, Ipsita Choudhary

Citation Information : Kishore PK, Choudhary I. Status and Effect of Vitamin D on Microvascular Complication in Type II Diabetes Mellitus Patients. Indian J Med Biochem 2017; 21 (1):34-37.

DOI: 10.5005/jp-journals-10054-0016

License: CC BY 3.0

Published Online: 00-06-2017

Copyright Statement:  Copyright © 2017; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Introduction

Vitamin D has a great impact on human health and disease. Recent studies proved that hypovitaminosis D is a possible risk factor for the pathogenesis of diabetes and its complications. In the present study, we evaluated vitamin D levels and its correlation with the duration of diabetes, sex, glycosylated hemoglobin (HbA1C), and microvascular complications in type II diabetes mellitus (T2DM) patients with and without microvascular complications.

Objectives

To study and correlate vitamin D levels and its relation with duration of diabetes, sex, glycemic control, and microvascular complication in T2DM patients with and without microvascular complications.

Materials and methods

Cross-sectional case–control study of 200 patients (35–70 years) suffering from T2DM was included. The T2DM patients without microvascular complications served as control group. Enrolled subjects underwent complete physical examination to detect the presence of microvascular complications, which includes microfilament tests, detailed fundus examination, urinary microalbumin/creatinine ratio. Fasting blood sugar, HbA1C, and serum vitamin D were also measured by using serum sample.

Results

Prevalence of vitamin D deficiency and insufficiency was found to be significantly higher in T2DM patients with microvascular complications (19.54 ± 2.56 vs 28.57 ± 2.93) as compared with T2DM patients without microvascular complications (p < 0.001). Hypovitaminosis D was found to be significantly more in females (60.75%) compared with males (39.96%) in both the study groups (p < 0.0001). Hypovitaminosis D was correlated with glycemic control and prevalence of microvascular complications.

Conclusion

Vitamin D is correlated with glycemic status and sex difference and has a role in pathogenesis of T2DM and its complications.

How to cite this article

Kishore PK, Choudhary I. Status and Effect of Vitamin D on Microvascular Complication in Type II Diabetes Mellitus Patients. Indian J Med Biochem 2017;21(1):34-37.


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