Glucose Fluctuations and Activation of Oxidative Stress in Patients with Type II Diabetes Mellitus

Reenu Sharma; Sunil S Patani; Maulik S Nayak

doi:10.5005/jp-journals-10054-0034

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Glucose Fluctuations and Activation of Oxidative Stress in Patients with Type II Diabetes Mellitus

Reenu Sharma, Sunil S Patani, Maulik S Nayak

Citation Information : Sharma R, Patani SS, Nayak MS. Glucose Fluctuations and Activation of Oxidative Stress in Patients with Type II Diabetes Mellitus. Indian J Med Biochem 2017; 21 (2):124-126.

DOI: 10.5005/jp-journals-10054-0034

License: CC BY 3.0

Published Online: 01-12-2013

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Abstract

Introduction

In recent years, the oxidative stress (OS)-induced free radicals have been implicated in the pathology of diabetes mellitus (DM). Persistently high glucose levels can lead to the generation of higher amounts of free radicals. The purpose of the present study was to evaluate the role of hyperglycemia [by measuring variables: Glycated hemoglobin (HbA1c), fasting plasma glucose (FPG)] in the induction of OS [(by analyzing the OS marker: Malondialdehyde (MDA)] in type II DM.

Materials and methods

This observational study was conducted among 50 type II DM patients without complications and 50 type II DM patients with complications in S.B.K.S. Medical Institute and Research Centre, Waghodiya, Gujarat, India. Correlations between variables were tested using the Pearson rho correlation test. Chi-squared (χ²) analysis was used for comparison of groups.

Results

The MDA values correlated significantly with HbA1c and FPG values in type II diabetic subjects with complications (r = +0.29, p = 0.04; r = +0.47, p = 0.0006).

Conclusion

Glucose fluctuations may activate OS in DM. Assessment of glycemic control marker HbA1c and lipid peroxidation marker MDA is useful in DM patients for detection of risk of diabetic complications at an early stage of the disease.

How to cite this article

Nayak MS, Sharma R, Patani SS. Glucose Fluctuations and Activation of Oxidative Stress in Patients with Type II Diabetes Mellitus. Indian J Med Biochem 2017;21(2):124-126.

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