Indian journal of Medical Biochemistry

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VOLUME 21 , ISSUE 2 ( July-December, 2017 ) > List of Articles

ORIGINAL ARTICLE

Study of Insulin Resistance in Women with Preeclampsia

Amit D Sonagra, Asmabi Makandar, Shivaleela M Biradar, Zahoorunissa Deba

Citation Information : Sonagra AD, Makandar A, Biradar SM, Deba Z. Study of Insulin Resistance in Women with Preeclampsia. Indian J Med Biochem 2017; 21 (2):127-130.

DOI: 10.5005/jp-journals-10054-0035

License: CC BY 3.0

Published Online: 01-12-2017

Copyright Statement:  Copyright © 2017; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Introduction

The root cause of preeclampsia is placental ischemia due to impaired trophoblastic invasion in the uterine spiral arterioles. Ischemic placenta liberates various inflammatory mediators that cause widespread endothelial dysfunction leading to insulin resistance (IR). Increased IR in pregnant females can further lead to high occurrence of maternal and fetal complications.

Objectives

To compare and evaluate the role of measuring IR among women with preeclampsia and normal pregnancy.

Materials and methods

A total of 35 women with preeclampsia and 35 women with normal pregnancy were included in the study as cases and controls, respectively. Fasting plasma glucose (FPG) and fasting plasma insulin (FI) were measured and IR indices, such as FPG to FI ratio (FGIR), quantitative insulin sensitivity check index (QUICKI), and log FI were calculated. Unpaired Student's t-test was used for comparison. Statistical analysis was done using Statistical Package for the Social Sciences (SPSS) version 17.0.

Results

The mean FI and log FI were significantly higher while QUICKI and FGIR were significantly lower in cases when compared with controls (p < 0.001).

Conclusion

As disease advances, IR increases. There is increased risk of maternal and fetal complications in presence of increased IR. Screening of all hypertensive pregnancies for IR and timely intervention may help to improve outcome.

How to cite this article

Sonagra AD, Deba Z, Makandar A, Biradar SM. Study of Insulin Resistance in Women with Preeclampsia. Indian J Med Biochem 2017;21(2):127-130.


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