Indian Journal of Medical Biochemistry

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VOLUME 21 , ISSUE 2 ( July-December, 2017 ) > List of Articles


Effect of Gestational Age and Birth Weight on Serum Creatinine in the First Week of Newborn Life

Vijaya L Ayyala, Narendra Devabathina, Prakash Gurappagari

Citation Information : Ayyala VL, Devabathina N, Gurappagari P. Effect of Gestational Age and Birth Weight on Serum Creatinine in the First Week of Newborn Life. Indian J Med Biochem 2017; 21 (2):131-135.

DOI: 10.5005/jp-journals-10054-0036

License: NA

Published Online: 01-12-2017

Copyright Statement:  NA



Serum creatinine concentration in health is essentially a function of muscle mass. We designed a prospective study to know the influence of gestational age and birth weight on creatinine in the first week of life.

Materials and methods

A total of 218 neonates were enrolled during a 2-year study period (May 2014—April 2016) at Kamineni Hospitals, Hyderabad, India. The study group was categorized based on gestational age [very preterm (VPT), preterm (PT), and term] and birth weight [very low birth weight (VLBW), low birth weight (LBW), and normal birth weight (NBW)]. The serum creatinine was assayed on the day of delivery in the mother and on days 0, 3, 5, and 7 in the neonates. The method of estimation of serum creatinine was by the modified kinetic Jaffe's reaction.


Serum creatinine was high in the VPT neonates (28—33 weeks of gestational age) and VLBW neonates (<1.5 kg) on day 0. An increase in mean serum creatinine was recorded on day 3 in VPT and VLBW neonates. Mean neonatal serum creatinine in all the subgroups based either on gestational age or birth weight decreased on day 7.


The serum creatinine in the first week of a newborn should be interpreted cautiously as the kidneys are in the process of maturation. High serum creatinine in neonates with insignificant muscle mass is a reflection of maternal serum creatinine coupled with an immature kidney.

How to cite this article

Ayyala VL, Devabathina N, Gurappagari P. Effect of Gestational Age and Birth Weight on Serum Creatinine in the First Week of Newborn Life. Indian J Med Biochem 2017;21(2):131-135.

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