Indian journal of Medical Biochemistry

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VOLUME 21 , ISSUE 2 ( July-December, 2017 ) > List of Articles

RESEARCH ARTICLE

Study of Parathyroid Hormone as an Independent Risk Marker of Heart Failure

Krishna M Iyyapu, Sreekanth Yerram, Kompella SS Sai Baba

Citation Information : Iyyapu KM, Yerram S, Sai Baba KS. Study of Parathyroid Hormone as an Independent Risk Marker of Heart Failure. Indian J Med Biochem 2017; 21 (2):157-161.

DOI: 10.5005/jp-journals-10054-0041

License: CC BY 3.0

Published Online: 00-12-2017

Copyright Statement:  Copyright © 2017; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Introduction

Heart failure (HF) is a clinical syndrome characterized by cardiac pump failure with signs and symptoms arising from salt and water retention. Heart failure is associated with considerable mortality and morbidity. Identification of modifiable risk factors may reduce incidence of HF and its complications. The aim of our study is to assess parathyroid hormone (PTH) as a risk marker for HF and its association with severity of HF.

Materials and methods

In this cross-sectional study, 120 subjects with HF were recruited and they were compared with 60 age- and sex-matched controls. Along with the routine parameters, N-terminal pro B-type natriuretic peptide (NT-proBNP), intact PTH, and vitamin D were estimated. The study group was divided into quartiles depending on PTH value.

Results

The median PTH (81.5 pg/mL) and NT-proBNP (3753 pg/mL) in HF patients are found to be significantly higher (p < 0.0001) when compared with control subjects. The median vitamin D concentration (18 ng/mL) though low in cases is not statistically significant when compared with controls. Demographic, clinical, and laboratory characteristics are compared across the quartiles of PTH. Highest number of New York Heart Association (NYHA) class IV HF cases are found in highest quartiles of PTH. Logistic regression analysis demonstrated that high concentration of PTH [odds ratio of 1.1113; 95% confidence interval (CI) 1.07—1.14; p < 0.0001] and low levels of vitamin D (odds ratio of 1.053; 95% CI 1.0079—1.1009) are significantly associated with HF.

Conclusion

This study has demonstrated that higher concentration of PTH is associated with severe form of HF. Vitamin D deficiency is also seen in the study group.

How to cite this article

Khan SA, Iyyapu KM, Sai Baba KSS, Yerram S. Study of Parathyroid Hormone as an Independent Risk Marker of Heart Failure. Indian J Med Biochem 2017;21(2):157-161.


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