Correlation of Serum Copper and Zinc Levels with Glycemic Status in Patients with Newly Diagnosed Uncomplicated Type II Diabetes Mellitus
Sarika Arora, Poonam Agarwal, Monica Verma, Bishamber D Tooraa
Copper, Glycated hemoglobin, Zinc
Citation Information :
Arora S, Agarwal P, Verma M, Tooraa BD. Correlation of Serum Copper and Zinc Levels with Glycemic Status in Patients with Newly Diagnosed Uncomplicated Type II Diabetes Mellitus. Indian J Med Biochem 2018; 22 (1):32-35.
Introduction: Diabetes mellitus (DM) is an epidemic facing the world today. The disease is characterized by a multitude of metabolic derangements which eventually lead to hyperglycemia and its associated complications. Trace elements, such as copper and zinc act as cofactors for essential enzymes of the metabolic pathways. Studies have reported conflicting results about their purported role in DM.
Materials and methods: The study was conducted on 22 newly diagnosed cases of type II DM (T2DM) and 30 age- and sexmatched healthy controls over a period of 2 months under the Indian Council of Medical Research Short Term Research Studentship (ICMR-STS) scheme. Blood glucose, serum zinc, copper, and glycated hemoglobin (HbA1c) levels were estimated using commercially available kits on Transasia XL 640. Data were collected and analyzed using appropriate statistical tests.
Results: The zinc levels were significantly decreased in the cases as compared with controls while there was no significant difference in the copper levels. A positive correlation between the copper and zinc levels was seen in the cases.
Conclusion: Trace elements play an important role in the maintenance of blood sugar levels and an in-depth understanding of the underlying pathways may help in a better management of DM.
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