Introduction: Meningitis is one of the most serious health issues. The World Health Organization (WHO) defines as inflammation of the meninges, the covering of brain, and spinal cord. Most common cause is by infection. It is always reported with very aggressive and devastating outcome on health and continues to cause significant morbidity and mortality worldwide. The current study is focused on bioprofiling of cerebrospinal fluid (CSF) which can be aided for early diagnosis of meningitis and helpful for differentiating meningitis from nonmeningitis for deciding treatment regimen by the treating clinician.
Objective: To study the biochemical parameters in meningitis patients and compare CSF bioprofile.
Materials and methods: It is an observational analytical study with a total of 60 subjects aged between 18 and 60 years, conducted in Father Muller Medical College Hospital, Mangaluru, for a duration of 3 months, after obtaining clearance from the institutional ethics committee. The samples sent for the analysis to the clinical biochemistry laboratory were collected and the same were used for the study after obtaining the informed consent from the patient. The traumatic samples and systemic disorder patient samples were excluded form the study. The parameters analyzed were: CSF C-reactive protein (CRP), CSF electrolytes, CSF aspartate transaminase (AST), and CSF lactate dehydrogenase (LDH) apart from the routine CSF protein and glucose in both group I (meningitis) and group II (nonmeningitis).
Results: The statistical analysis was performed using the Statistical Package for the Social Sciences (SPSS) version 23, with the significance value of 0.05. The mean of the CSF CRP was 2.0 ± 1.12 in group I compared with group II 0.09 ± 0.15; CSF AST was 17.42 ± 6.24, 5.1 ± 3.8 in groups I and II respectively; and CSF LDH was 211.1 ± 49.0, 23.71 ± 10.29 in groups I and II respectively, with p-value < 0.001 (highly significant).
Conclusion: The CSF CRP was found to be increased in patients with meningitis compared with the negative CSF, and the significant increase in the CSF AST and LDH; this knowledge can help to aid the routine CSF protein and glucose to differentiate the meningitis before the result of the culture is reported for deciding the treatment regimen.
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