Citation Information :
Vyakaranam S, Kondaveedu S, Nori S, Dandge S, Bhongir AV. Study of Serum High-sensitivity C-reactive Protein in Subclinical Hypothyroidism. Indian J Med Biochem 2018; 22 (1):66-70.
Aim: The aim of the study is to see the difference between high-sensitivity C-reactive protein (hsCRP) in subclinical hypothyroidism (SCH) and controls and find an association between hsCRP and thyroid-stimulating hormone (TSH) in SCH.
Materials and methods: Totally, 60 subjects were selected for the study, which included 30 cases of SCH and 30 controls with normal thyroid status.
Results: The mean TSH levels were significantly elevated in SCH when compared with controls (9.20 ± 2.12 mU/mL; 2.26 ± 0.78 mU/mL; p-value: <0.0001 respectively). Significantly elevated hsCRP was observed in SCH when compared with controls (3.05 ± 1.78 mg/L; 0.62 ± 0.39 mg/L; p < 0.0001 respectively). As per stratification of cardiovascular disease (CVD) risk by hsCRP, 23% of SCH had high risk of developing CVD. Multivariate linear regression suggested that hsCRP is significantly and positively associated with SCH after adjusting for age and body mass index (BMI).
Conclusion: Elevated levels of hsCRP in SCH suggest inflammation as a possible factor for linking SCH and CVD.
Clinical significance: Progression to overt hypothyroidism and cardiovascular risk are the major implications of SCH. The hsCRP is not only an inflammatory marker, but also a stimulator of inflammation and predictor of CVD. The hsCRP indicates the cardiovascular risk associated with SCH. Hence, it can be used to screen SCH patients who are at a risk of developing CVD.
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