Introduction: In a routine clinical laboratory having more than one automated system, comparison of methods experiment provides a means to assess any method\'s performance. It helps to estimate systematic (constant and proportional) difference between two methods. If the difference between two methods is small and clinically acceptable, then these two methods can be used interchangeably. In this study, we have compared direct bilirubin on two automated systems and tried to analyze the cause behind the difference between the two.
Materials and methods: Serum samples obtained from normal individuals as well as those with unconjugated and conjugated hyperbilirubinemia were analyzed on Cobas 6000 and Olympus AU 2700 simultaneously.
Results: There was a significant difference in the values of direct bilirubin in patients with conjugated hyperbilirubinemia on the two automated systems. No difference was seen in normal persons and in patients with unconjugated hyperbilirubinemia.
Conclusion: Delta bilirubin might be a contributing factor to the difference between direct bilirubin on the two systems, as it is expected only in patients with conjugated hyperbilirubinemia.
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