Introduction: As we know, endothelial dysfunction (ED) is an initial stage of vascular complications in type II diabetes mellitus. Hypoglycemic drugs have shown beneficial effect on endothelial function. Insulin is a regulatory hormone for endothelial function in vessels. But, there was a controversial report on the effect of exogenous insulin on endothelial function in type II diabetes subjects. Aim and objective: The study has been designed to observe the effect of insulin therapy on ED in type II diabetic subjects without any complications. Result: Significantly high level of body mass index (BMI) was identified in insulin-treated subjects than subjects with hypoglycemic drugs and healthy controls. Nitric oxide (NO) has been shown to be significantly lower in insulin-treated subjects compared to subjects with hypoglycemic drugs and healthy controls. There was no significant change in the levels of lipid profile and oxidative stress between two treatment groups. Conclusion: Significant effect of insulin therapy was observed on ED in type II diabetes mellitus. Exogenous insulin itself may cause ED by hyperinsulinemia due to high-fat diet or high dosage of insulin.
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