Indian Journal of Medical Biochemistry

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VOLUME 23 , ISSUE 1 ( January-April, 2019 ) > List of Articles

Original Article

Evaluation of Thyroid Profile and Complement ‘C3’ in Metabolic Syndrome

Ivvala A Shaker, Suritha PK, Neha D Sheth, Inampudi Sailaja

Keywords : FPG, PPG, FT3, FT4, TSH, HbA1c, Serum complement C3

Citation Information : Shaker IA, PK S, Sheth ND, Sailaja I. Evaluation of Thyroid Profile and Complement ‘C3’ in Metabolic Syndrome. Indian J Med Biochem 2019; 23 (1):197-202.

DOI: 10.5005/jp-journals-10054-0085

License: CC BY-NC 4.0

Published Online: 01-04-2019

Copyright Statement:  Copyright © 2019; The Author(s).


Diabetes mellitus (DM) is associated with thyroid dysfunction. The aim of this present study was to measure the level of thyroid hormones (FT3, FT4, TSH), FPG, PPG, HBA1C, serum C3 in type II diabetic patients of either sex and to assess their clinical presentations and to compare and correlate the findings with males and females. In this study, 177 type II diabetic subjects and 100 healthy control subjects were investigated for FT3, FT4, and TSH. FPG, PPG, HbA1C, and S C3 complement were measured as supplementary parameters to predict the immune system. The level of TSH was significantly higher in type II diabetics as compared to control, but FT3 and FT4 did not show statistical significance. Significantly higher levels of FPG, PPG, HbA1C, and serum C3 and were also noted but serum C3 showed a significant increase with some immune dysfunction compared to control subjects. Type II diabetes should undergo regular screening to detect asymptomatic thyroid dysfunction along with complement C3 and other biochemical parameters to improve the quality of life and reduce the complication rate.

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  1. Bando U, Ushiogi Y, Toya D, et al. Diabetic nephropathy accompanied by iodine induced nonautoimmuneprimary hypothyroidism: two cases report. Endocrinol J 1999;46 (6):803-810.
  2. Bergesio F, Bandini S, Cresci B, et al. Hyperthyroidism: Is it really the major factor affecting glucose tolerance in ureamia. Electrolyte Metab 1996;22(1-3):187-191.
  3. Sperling MA, Jenson BK. Diabetes In: Nelson textbook of paediatrics 16th edition, USA:WB Saunders Company 2000; pp.1348-1349.
  4. Pasupathi P, Bakthavathsalam G, Saravanan G, et al. Screening for thyroid dysfunction in the diabetic/non-diabetic population. Thyroid Science 2008; 3(8):1-6.
  5. Dias CM, Nogueira P, Rosa AN, et al. Total cholesterol and high-density cholesterol in patients with insulin dependent diabetes mellitus. Acta Medica 1995;8:619-628.
  6. Swamy RM, Kumar N, Srinivasa K, et al. Evaluation of hypothyroidism as a complication in Type II Diabetes Mellitus. Biomedical Research 2012;23(2):170-172.
  7. Calvo R, Escobar MG, Rey EFet al. Maternal nonthyroidal illness and fetal thyroid hormone status, as studied in the streptozotocininduced diabetes mellitus rat model. Endocrinol. 1997;138:1159-1169.
  8. Suzuki J, Nanno M, Gemma R, et al. The mechanism of thyroid hormone abnormalities inpatients with diabetes mellitus. Nippon Niabunpi. Gakki. Zasshi 1994; 7(4): 465-470.
  9. Donckier JE. Endocrine diseases and diabetes. In: Text book of Diabetes mellitus. Pickup JC, Williams G (eds), Blackwell Publishing Company, Chichester 2003:27.1-27.25.
  10. Schlienger JL, Anceau A, Chabrier G, et al. Effect of diabetic control on the level of circulating thyroid hormones. Diabetologia. 1982;22;486-488.
  11. Hertle E, Van Greevenbroek, MM, Stehouwer CD. Complement C3: An emerging risk factor in cardicometabolic disease. Diabetologia 2012, Apr;55(4):881-884.
  12. Trinder P. Determination of glucose in serum, plasma and CSF, GOD/ POD method. Ann Clin Biochem 1996; 6:24-27.
  13. Nobre EL, Jorge Z, Prata S, et al. Profile of the thyroid function in a population with type-2 diabetes mellitus 2002:298-300.
  14. Ramasamy V, Kadiyala R, Fayyaz F, et al. Value of a baseline serum thyrotropin as a predictor of hypothyroidism in patients with diabetes. Endocrine Practice 2010;14:1-25.
  15. Beck-Pacozz P, Persani L. Variable biological activity of thyroid stimulating hormone. Europian journal of Endocrinol 1994;31: 331-340.
  16. Serum complement C3, Estimation. Agappe diagnostic LTD. Feb 2015.
  17. Engbeak F, Christensens SE, Jespersen B. Enzyme immunoassay of hemoglobin A1C; Analytical characteristics & Clinical performance for patients with diabetes mellitus, with and without Uremia. Clin Chem 1989;35:93-97.
  18. Sathish R, Mohan V. Diabetes and thyroid diseases - a review. Int J Diab Dev Countries 2003;23:120-123.
  19. Hage M, Zantout MS, Azar ST. Thyroid disorders and diabetes mellitus. Journal of thyroid research 2011;2011:1-7.
  20. Hessa T, Al Wazzan, Daban A, et al. Prevalence and associated factors for thyroid dysfunction among type 2 diabetic patients, kuwait. Alexandria bulletin 2010;46(2):141-148.
  21. Udiong CE, Udoh AE, Etukudoh ME. Evaluation of thyroid function in Diabetes Mellitus in calabar, nigeria. Indian Journal of Clinical Biochemistry 2007;22(2):74-78.
  22. De-Greef WJ, Rondeel JM, Van-Haasteren GA, et al. Regulation of TRH production and release in rats. Acta Medica Austriaca 1992;19(1):77-79.
  23. Mannheim B. Extrathyroidal factor affecting thyroidhormone concentration. Rational approach to thyroiddiagnosis, GmbH, Boehringer Mannheim. 1984;2-4.
  24. Cettour-Rose P, Theander-Carrillo C, Asensio C, et al., Hypothyroidism in rats decreases peripheral glucose utilisa-tion, a defect partially corrected by central leptin infusion. Diabetologia 2005; 48(4): 624-633.
  25. Maratou E, Hadjidakis DJ, Kollias A, et al. Studies of insulin resistance in patients with clinical and subclinical hypothyroidism, European Journal of Endocrinology 2009;160(5):785-790.
  26. Chen HS, Wu TEJ, Jap TS, et al. Subclinical hypothy-roidism is a risk factor for nephropathy and cardiovascular diseases in Type 2 diabetic patients. Diabetic Medicine 2007;24(12):1336-1344.
  27. Den Hollander JG, Wulkan RW, et al. Correlation between severity of thyroid dysfunction and renal function. Clinical Endocrinology 2005;62(4):423-427.
  28. Yang GR, Yang JK, Zhang L, et al. Association between subclinical hypothyroidism and proliferative diabetic retinopathy in type 2 diabetic patients: a case-control study. Tohoku Journal of Experimental Medicine 2010;222(4):303-310.
  29. Wlazlo N, Marleen M.J. van Greevenbroek, Isabel Ferreira, Edith J.M. Feskens, et. al. Complement Factor 3 Is Associated With Insulin Resistance and With Incident Type 2 Diabetes Mellitus Over a 7-Year Follow-up Period: The CODAM Study. Diabetes Care 2014;4: 132804.
  30. Akinlade KS, Arinola OG, Salimonu LS, et al. Circulating immune complexes, immunoglobulin classes (IgG, IgA and IgM) and complement components (C3, C4 and Factor B) in diabetic Nigerians. West Afr J Med 2004.
  31. Musch W, Verfaillie L, Decaux G. Age-Related Increase in Plasma Urea Level and Decrease in Fractional Urea Excretion: Clinical Application in the Syndrome of Inappropriate Secretion of Antidiuretic Hormone. Clin J Am Soc Nephrol 2006;1:909-914
  32. Islam S, Yesmine S, Khan SA, et al. A comparative study of thyroid hormone levels In diabetic and non-diabetic patients. Southeast Asian J Trop Med Public Health 2008;39(5):913-916.
  33. Smithson, MJ. Screening for thyroid dysfunction in a community population of diabetic patients. Diabet Med 1998;15:148-150.
  34. Roos A, Bakker SJ, Links TP, et al. Thyroid function is associated with components of the metabolic syndrome in euthyroid subjects. Journal of Clinical Endocrinology and Metabolism 2007;92:491-496.
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