Indian Journal of Medical Biochemistry

Register      Login

VOLUME 23 , ISSUE 2 ( May-August, 2019 ) > List of Articles

Original Article

Effect of Hemodialysis on Trace Elements in Renal Failure Patients

Anusha P Dsouza, Ramlingareddy, Anurag Yadav, Malathi Mala

Keywords : Chronic renal failure, Hemodialysis, Iron, Zinc

Citation Information : Dsouza AP, R, Yadav A, Mala M. Effect of Hemodialysis on Trace Elements in Renal Failure Patients. Indian J Med Biochem 2019; 23 (2):233-235.

DOI: 10.5005/jp-journals-10054-0093

License: CC BY-NC 4.0

Published Online: 01-06-2019

Copyright Statement:  Copyright © 2019; The Author(s).


Hemodialysis patients are at prone for essential trace element deficiency and accumulation of excess harmful trace elements, together of which can affect health burden. During dialysis required renal functions, such as the removal of metabolic waste products, water, correction of the acid-base status and electrolytes are substituted by the artificial purification system. Prone for both accumulation and deficiency of trace elements depends on removal by dialysis, dietary intake, the content of the source water used for dialysis and residual kidney function. This study aimed to evaluate the possible changes in serum iron (Fe) and zinc (Zn) levels in CRF patients undergoing dialysis, pre, and post. It is a case-control hospital-based study (n = 90), Patients included in the present study were all admitted to the Nephrology unit or attending the outpatient department of Nephrology and Dialysis ward. Group IA- Pre-hemodialysis, Group IB- Post-haemodialysis, Group II- Normal healthy controls. Results showed serum zinc levels in both groups of CRF patients (IA, IB) were significantly higher when compared to controls. There was a significantly higher serum level of iron in Group-IB when compared to Group-1A patients. To conclude, the present study has observed significant changes in zinc and iron in CRF patients, pre- and post-hemodialysis.

PDF Share
  1. Tonelli M, Wiebe N, Hemmelgarn B, Klarenbach S, Field C, Manns B et al. Trace elements in hemodialysis patients: a systematic review and meta-analysis. BMC Medicine. 2009;7:25.
  2. Meerashivashekar, William WE, Revathi R, Padmanabhan. Effect of oxidative stress in pre and post hemodialysis in chronic renal failure. 2012;1:1335-1337.
  3. Krachler M, Scharfetter H, Wirnsberger G. kinetics of the metal cations magnesium, calcium, copper, zinc, strontium, barium and lead in chronic hemodialysis patients. Clin Nephrol. 2000;54:35-44.
  4. Rajashri BB, Adinath NS, Nitin GJ. Effect of Hemodialysis on Serum Copper and Zinc Levels in Renal Failure Patients. Eur J Gen Med. 2013;10:154-157.
  5. Smythe WR, Alfrey AC, Craswel PW, Crouch CA, Ibels LS, Kubo H, et al. Trace elements abnormalities in chronic uremia. Ann Intern Med. 1982;96:302-310.
  6. Burtis CA, Ashwood ER, Burns DE, editors. Tietz Text Book of Clinical Chemistry and Molecular Diagnostics, 5th edition; Elsevier and Saunders: St.Louis; 2012.
  7. Makino T. A sensitive, direct colorimetric assay of serum zinc using nitro-PAPS and microwell plates. Clin Chim Acta. 1991;197:209-220.
  8. Hsieh YY, Shen WS, Lee LY, Wu TL, Ning HC, Sun CF. Longterm changes in trace elements in patients undergoing chronic hemodialysis. Biol Trace Elem Res. 2006;109:115-17.
  9. Vanholder R, Cornelis R, Dhondt A, Lameire N. The role of trace elements in uraemic toxicity. Nephrol Dial Transplant. 2002;17:2-8.
  10. Covic A, Gusbeth-Tatomir P. Trace elements in endstage renal disease – unfamiliar territory to be revealed. BMC Nephrology. 2009;10:12.
  11. Krachler M, Scharfetter H, Wirnsberger GH. Kinetics of the metal cations magnesium, calcium, copper, zinc, strontium, barium, and lead in chronic hemodialysis patients. Clin Nephrol. 2000;54:35-44.
  12. Kalantar-Zadeh K, Kopple JD. Trace elements and vitamins in maintenance dialysis patients. Adv Ren Replace Ther. 2000;10:170-182.
  13. Guo CH, Wang CL, Chen PC, Yang TC. Linkage of some trace elements, peripheral blood lymphocytes, inflammation, and oxidative stress in pacients undergoing either hemodialysis or peritoneal dialysis. Perit Dial Int 2011;31:583-591.
  14. Tetiker T, Paydas S, Yuregir G, Sagliker Y. Trace elements alternations in chronic hemodialysis patients with chronic renal failure and Proteinuria. Journal of Islamic Academy of Sciences. 1993;1:33-35.
  15. Paydas S, Albayrak A, Yuregir G, Sagliker Y, Demirci C, Gurcay A. Trace elements in hemodialysis patients. Third international congress on Trace elements in health and Disease.1989:615.
  16. Swaminathan S, Fonesca VA, Alam M.G, and Shah SV. The role of Iron in Diabetes and its complications. Diabetic Care (ADA). 2007;30:1926-1933.
  17. Rostoker G, Griuncelli M, Loridon C et al. Hemodialysis-associated hemosiderosis in the era of erythropoiesis-stimulating agents: a MRI study. Am J Med. 2012;125: 991–999.
  18. Steven F, Anna M, Nosratola DV. Iron toxicity: relevance for dialysis patients. Nephrol Dial Transplant. 2013 ;1:1093-1099.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.