Association of Serum Hs-CRP with Urinary Albumin Creatinine Ratio and Lipid Profile in Diabetic Individuals Attending a Tertiary Care Hospital in the Sub-Himalayan Belt
Dona Acharjya, Swati Bhattacharyya, Ushasi Banerjee, Mita Saha, Ashok Ghosh
Diabetes, Hs-CRP, Lipid profile,ACR
Citation Information :
Acharjya D, Bhattacharyya S, Banerjee U, Saha M, Ghosh A. Association of Serum Hs-CRP with Urinary Albumin Creatinine Ratio and Lipid Profile in Diabetic Individuals Attending a Tertiary Care Hospital in the Sub-Himalayan Belt. Indian J Med Biochem 2019; 23 (2):247-249.
Aims: The aim of the study was to show a simultaneous increase of high sensitive C-reactive protein (hs-CRP) with a degree of renal involvement suggested by albumin-creatinine ratio and dyslipidemia in diabetic patients, as the period of diabetes progresses. No such duration based study has ever been conducted so far in the sub-Himalayan region and fringe area including different ecosystem as in the present study.
Materials and methods: It was an Institution based observational comparative study conducted in a tertiary care hospital in sub-Himalayan belt from April 2016 to March 2017 among 120 diabetic individuals aged (30–60) years irrespective of gender, divided into 3 groups of 40 subjects in each, namely: (a) newly diagnosed <5 years, (b) 5–10 years after diagnosis and, (c) ≥10 years after diagnosis. Research variables were hs-CRP, urinary ACR and lipid profile.
Results: Descriptive studies showed that mean values of hs-CRP were 0.04 ± 0.005, 0.08 ± 0.011, and 0.10 ± 0.017 and that of ACR were 100.29 ± 11.59, 117.65 ± 6.93 and 128.80 ± 7.91 in groups 1, 2, 3, respectively. One-way analysis of variance (ANOVA) with post hoc analysis after Bonferroni correction between different groups enunciated that both hs-CRP and ACR increased significantly and statistically (p <0.001) with a duration of diabetes in all three groups unlike the parameters of lipid profile. Hs-CRP, ACR, cholesterol and LDL even illustrated a very significant correlation between each other (p <0.001) whereas TG and HDL have shown correlations neither to themselves nor other parameters.
Conclusion: Early detection, monitoring of inflammatory markers hs-CRP and ACR as predictors of diabetic nephropathy can help in modulating diabetes and its complications.
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