Introduction: Antinuclear antibodies (ANA) are the most commonly evaluated non specific autoantibodies in clinical practice. Previous studies showed ANAs are frequently detected in healthy individuals and expression of ANAs are more common in women and older age groups. To explain the reason of sex differences differential chromosomal, hormonal and reproductive factors are postulated, but till now the association is not clearly understood. There is paucity of Indian data of ANA status amongst women. In this study we examined the relationship of ANA status with socio demographic and reproductive factors in a representative sample of non pregnant adult Indian women.
Aims and Objectives:
• Estimation of ANA status prevalence in non pregnant Indian women by enzyme linked immunosorbent assay (ELISA) technique.
• Effects of socio demographic and reproductive factors with ANA prevalence.
Materials and methods: This study was conducted in the zonal level hospital. Non pregnant adult women who had ever menstruated and voluntarily completed the socio demographic and reproductive history questionnaire were included in the study. Serum ANA screening test were performed for the detection of IgG class antibodies to ANA in human serum by ELISA.
Results: We analyzed data on socio demographic and reproductive factors in relation to serum ANA status in adult non pregnant females using SPSS statistical software. The values thus obtained statistically similar with those obtained in developed countries.
Conclusion: These findings highlight the importance of considering sociodemographic and reproductive history in studies of autoimmunity in women in Indian set up.
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