Objective: Magnesium (Mg) plays a crucial role in vitamin D synthesis and metabolism. In magnesium-dependent vitamin-D-resistant rickets supplementation of this micronutrient changed the resistance to vitamin D treatment significantly. This study aims to evaluate the correlation between serum Mg and vitamin D total levels in an otherwise healthy individual. We hypothesized that in hypovitaminosis D, there is also a Hypomagnesaemia as well.
Materials and methods: The study population comprises of 252 young patients, aged between 18 years and 45 years, consisting of individuals with and without hypovitaminosis D. The correlation between measured serum 25 hydroxyvitamin D total (25(OH) D) magnesium and calcium level concentrations were studied.
Results: The mean age of the studied population was 31.5 ± 2.32 years, and studied groups, i.e. those with hypovitaminosis D and those without it were age matched. The mean 25 OH Vitamin D Total, Ca, and Mg level in the total study population was 20.32 ± 6.84 ng/mL, 9.6 ± 0.52 mg/dL, 2.24 ± 0.22 mg/dL, respectively. The mean serum 25(OH) D level was 23.62±2.12 in vitamin D insufficient group; however, it was 14.84 ± 2.74 in vitamin D deficient cases. The mean serum Mg level was 2.27±0.18 mg/dL in the vitamin D insufficient group, and it was 2.23 ± 0.25 in the vitamin D deficient group.
Conclusion: In our study, we have demonstrated that there is no statistically significant associations exist between measured serum Mg and 25(OH) total vitamin D levels. Level of vitamin D and serum Mg is independent of each other and taking vit D alone is sufficient enough to combat hypovitaminosis D. However, further large longitudinal studies are desirable to evaluate the causal mechanisms and the clinical connotation of the current findings.
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