Indian journal of Medical Biochemistry

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VOLUME 23 , ISSUE 2 ( May-August, 2019 ) > List of Articles

Original Article

Is Magnesium Required for Optimal Level of Serum Vitamin D? A Hospital-based Study

SK Rai, Barun K Chakrabarty, Mukul Bajpai, Vimal Upreti

Keywords : Hypovitaminosis D, Magnesium, Vitamin D

Citation Information : Rai S, Chakrabarty BK, Bajpai M, Upreti V. Is Magnesium Required for Optimal Level of Serum Vitamin D? A Hospital-based Study. Indian J Med Biochem 2019; 23 (2):254-258.

DOI: 10.5005/jp-journals-10054-0098

License: CC BY-NC 4.0

Published Online: 01-08-2019

Copyright Statement:  Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Objective: Magnesium (Mg) plays a crucial role in vitamin D synthesis and metabolism. In magnesium-dependent vitamin-D-resistant rickets supplementation of this micronutrient changed the resistance to vitamin D treatment significantly. This study aims to evaluate the correlation between serum Mg and vitamin D total levels in an otherwise healthy individual. We hypothesized that in hypovitaminosis D, there is also a Hypomagnesaemia as well. Materials and methods: The study population comprises of 252 young patients, aged between 18 years and 45 years, consisting of individuals with and without hypovitaminosis D. The correlation between measured serum 25 hydroxyvitamin D total (25(OH) D) magnesium and calcium level concentrations were studied. Results: The mean age of the studied population was 31.5 ± 2.32 years, and studied groups, i.e. those with hypovitaminosis D and those without it were age matched. The mean 25 OH Vitamin D Total, Ca, and Mg level in the total study population was 20.32 ± 6.84 ng/mL, 9.6 ± 0.52 mg/dL, 2.24 ± 0.22 mg/dL, respectively. The mean serum 25(OH) D level was 23.62±2.12 in vitamin D insufficient group; however, it was 14.84 ± 2.74 in vitamin D deficient cases. The mean serum Mg level was 2.27±0.18 mg/dL in the vitamin D insufficient group, and it was 2.23 ± 0.25 in the vitamin D deficient group. Conclusion: In our study, we have demonstrated that there is no statistically significant associations exist between measured serum Mg and 25(OH) total vitamin D levels. Level of vitamin D and serum Mg is independent of each other and taking vit D alone is sufficient enough to combat hypovitaminosis D. However, further large longitudinal studies are desirable to evaluate the causal mechanisms and the clinical connotation of the current findings.


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  1. Gessner BD, Plotnik J, Muth PT. 25-Hydroxyvitamin D levels among healthy children in Alaska. The Journal of pediatrics. 2003 Oct 1;143(4):434-437.
  2. Ceglia L. Vitamin D and its role in skeletal muscle. Current opinion in clinical nutrition and metabolic care. 2009 Nov;12(6):628.
  3. Torun E, Gönüllü E, Özgen İT, Cindemir E, Öktem F. Vitamin d deficiency and insufficiency in obese children and adolescents and its relationship with insulin resistance. International journal of endocrinology. 2013;2013.
  4. Ziegler EE, Hollis BW, Nelson SE, Jeter JM. Vitamin D deficiency in breastfed infants in Iowa. Pediatrics. 2006 Aug 1;118(2):603-610.
  5. Nucci AM, Russell CS, Luo R, Ganji V, Olabopo F, Hopkins B, Holick MF, Rajakumar K. The effectiveness of a short food frequency questionnaire in determining vitamin D intake in children. Dermato-endocrinology. 2013 Jan 1;5(1):205-210.
  6. Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics. 2008 Aug 1;122(2):398-417.
  7. Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentration of 25-hdyroxyvitamin D for multiple health outcomes [published correction appears in Am J Clin Nutr. 2006;84(5):1253] Am J Clin Nutr. 2006;84(1):18-28.
  8. Lips P. Vitamin D physiology. Prog Biophys Mol Biol. 2006;92:4-8.
  9. Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, Fuleihan GE, Josse RG, Lips P, Morales-Torres J, IOF Committee of Scientific Advisors (CSA) Nutrition Working Group. Global vitamin D status and determinants of hypovitaminosis D. Osteoporosis international. 2009 Nov 1;20(11):1807-1820.
  10. Marcus MB. Vitamin D tests soar as deficiency, diseases linked. USA Today. 2008 Jul 14;13.
  11. Kelishadi R, Sharifi-Ghazvini F, Poursafa P, Mehrabian F, Farajian S, Yousefy H, Movahedian M, Sharifi-Ghazvini S. Determinants of hypovitaminosis d in pregnant women and their newborns in a sunny region. International journal of endocrinology. 2013;2013.
  12. Ardestani PM, Salek M, Keshteli AH, Nejadnik H, Amini M, Hosseini SM, Rafati H, Kelishadi R, Hashemipour M. Vitamin D status of 6-to 7-year-old children living in Isfahan, Iran. Endokrynologia Polska. 2010;61(4):377-382.
  13. Zhu Z, Zhan J, Shao J, Chen W, Chen L, Li W, Ji C, Zhao Z. High prevalence of vitamin D deficiency among children aged 1 month to 16 years in Hangzhou, China. BMC public health. 2012 Dec;12(1):126.
  14. Harinarayan CV, Ramalakshmi T, Prasad UV, Sudhakar D. Vitamin D status in Andhra Pradesh: a population based study. Indian Journal of Medical Research. 2008 Mar 1;127(3):211.
  15. Pramyothin P, Holick MF. Vitamin D supplementation: guidelines and evidence for subclinical deficiency. Current opinion in gastroenterology. 2012 Mar 1;28(2):139-150.
  16. Reddy P, Edwards LR. Magnesium Supplementation in Vitamin D Deficiency. Am J Ther. 2017 May 3.
  17. Wagner CL, Greer FR. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics. 2008 Nov 1;122(5):1142-1152.
  18. Garland CF, French CB, Baggerly LL, Heaney RP. Vitamin D supplement doses and serum 25-hydroxyvitamin D in the range associated with cancer prevention. Anticancer research. 2011 Feb 1;31(2):607-611.
  19. Whang R. Magnesium deficiency: pathogenesis, prevalence, and clinical implications. The American journal of medicine. 1987 Mar 20;82(3):24-29.
  20. Ardawi MS, Sibiany AM, Bakhsh TM, Qari MH, Maimani AA. High prevalence of vitamin D deficiency among healthy Saudi Arabian men: relationship to bone mineral density, parathyroid hormone, bone turnover markers, and lifestyle factors. Osteoporosis International. 2012 Feb 1;23(2):675-686.
  21. Polidoro L, Properzi G, Marampon F, Gravina GL, Festuccia C, Di Cesare E, Scarsella L, Ciccarelli C, Zani BM, Ferri C. Vitamin D protects human endothelial cells from H 2 O 2 oxidant injury through the Mek/Erk-Sirt1 axis activation. Journal of cardiovascular translational research. 2013 Apr 1;6(2):221-231.
  22. Tylavsky FA, Cheng S, Lyytikäinen A, Viljakainen H, Lamberg-Allardt C. Strategies to improve vitamin D status in northern European children: exploring the merits of vitamin D fortification and supplementation. The Journal of nutrition. 2006 Apr 1;136(4):1130-1134.
  23. Schnabel C, Jett K, Friedman JM, Frieling I, Kruse HP, Mautner V. Effect of vitamin D3 treatment on bone density in neurofibromatosis 1 patients: a retrospective clinical study. Joint Bone Spine. 2013 May 1;80(3):315-319.
  24. Brehm JM, Celedón JC, Soto-Quiros ME, Avila L, Hunninghake GM, Forno E, Laskey D, Sylvia JS, Hollis BW, Weiss ST, Litonjua AA. Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. American journal of respiratory and critical care medicine. 2009 May 1;179(9):765-771.
  25. Kelishadi R, Salek S, Salek M, Hashemipour M, Movahedian M. Effects of vitamin D supplementation on insulin resistance and cardiometabolic risk factors in children with metabolic syndrome: a triple-masked controlled trial. Jornal de pediatria. 2014 Feb;90(1):28-34.
  26. Deng X, Song Y, Manson JE, Signorello LB, Zhang SM, Shrubsole MJ, Ness RM, Seidner DL, Dai Q. Magnesium, vitamin D status and mortality: results from US National Health and Nutrition Examination Survey (NHANES) 2001 to 2006 and NHANES III. BMC medicine. 2013 Dec;11(1):187.
  27. Vojtková J, Ciljaková M, Vojarová L, Janíková K, Michnová Z, Sagiová V. Hypovitaminosis D in children with type 1 diabetes mellitus and its influence on biochemical and densitometric parameters. acta Medica (hradec Králové). 2012 May;55(1):18-22.
  28. Sahota O, Mundey MK, San P, Godber IM, Hosking DJ. Vitamin D insufficiency and the blunted PTH response in established osteoporosis: the role of magnesium deficiency. Osteoporosis international. 2006 Jul 1;17(7):1013-1021.
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