Background: Alcoholic liver disease (ALD) is most prevalent in Sikkim where its consumption is a common practice and accepted socially.
Materials and methods: Fifty male patients and normal healthy groups were taken for the study. Direct and total bilirubin, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase (ALP), and reduced glutathione along with the relationship with age group and ethnicity were assessed.
Results and conclusion: Biochemical parameters such as direct (1.6 ± 1.0) and total bilirubin (2.9 ± 1.5), aspartate aminotransferase (68.7 ± 1.629), alanine aminotransferase (29.8 ± 6.5), ALP (1.4 ± 3.4), gamma-glutamyl transferase (1.18 ± 8.4) were observed to be increased and oxidative stress markers like glutathione was decreased in patients with alcoholic liver disease. Highest number of patients with the disease were between 36 and 46 years (44%) of age and in Kiratis (40%). This is a first attempt to study the ALD based on age group and ethnicity. Various programs should initiated to prevent alcohol abuse.
Jaurigue MM, Cappell MS. Therapy for alcoholic liver disease. World J Gastroenterol 2014;20(9):2143–2158. DOI: 10.3748/wjg.v20.i9.2143.
O'Shea RS, Dasarathy S, McCullough AJ. Alcoholic liver disease: AASLD Practice Guidelines. Hepatology 2010;51(1):307–328. DOI: 10.1002/hep.23258.
Tsukamoto H. Conceptual importance of identifying alcoholic liver disease as a lifestyle disease. J Gastroenterol 2007;42(8):603–609. DOI: 10.1007/s00535-007-2075-3.
National Institute of Alcohol Abuse and Alcoholism, U.S Department of Health and Human Services, The Physicians' guide to helping patients with alcohol problems. Washington, DC: Government Printing Office; 1995.
National Family Health Survey-4, 2015–2016. Ministry of Health and Family Welfare, Government of India. International Institute of Population Sciences, Mumbai.
Hagymasi K, Blazovics A, Lengyel G, et al. Oxidative damage in alcoholic liver disease. Eur J Gastroenterol Hepatol 2001;13(1):49–53. DOI: 10.1097/00042737-200101000-00009.
Sathian B, Sreedharan J, Baboo NS, et al. Relevance of sample size determination in medical research. Nepal J Epidemiol 2010;1(1): 9–10.
Jendrassik L, Grof P. Colorimetric method of determination of bilirubin. Biochem Z 1938;297:81–82.
Thefelt W, Hoffmeister H, Busch EW, et al. Reference values for the determination of GOT, GPT, and alkaline phosphatase in serum with optimal standard methods. Dtsch Med Wschr 1974;99(8):343.
Bergmeyer HU, Horder M. IFCC methods for the measurement of catalytic concentrations of enzymes. part 3, IFCC. Method for alanine aminotransferase (l-alanine 2 -oxoglutarate aminotransferase, ec 126.96.36.199)Clin Chem Acta 1980;105(1):147–172. DOI: 10.1016/0009-8981(80)90105-9.
Beutler E, Duron O, Kelly BM. Improved method for the determination of blood glutathione. J lab Clin Med 1963;61:882–888.
Nyblom H, Berggren U, Balldin J, et al. High AST/ALT ratio may indicate advanced alcoholic liver disease rather than heavy drinking. Alcohol Alcohol 2000;39(4):336–339. DOI: 10.1093/alcalc/agh074.
Nyblom H, Björnsson E, Simrén M, et al. The AST/ALT ratio as an indicator of cirrhosis in patients with PBC. Liver Int September 2006;26(7):840–845. DOI: 10.1111/j.1478-3231.2006.01304.x.
Gopal DV, Rosen HR. Abnormal findings on liver function tests. Interpreting results to narrow the diagnosis and establish a prognosis. Postgrad Med 2000;107(2):100–102. DOI: 10.3810/pgm.2000.02.869, 105–109, 113–114.
Desai M. Eco System and Ethnic Constellation of Sikkim. Calcutta: Netaji Institute of Asian Studies; 1988. p. 39.
Das SK, Nayak P, Vasudevan DM. Biochemical Markers for Alcohol Consumption. Ind J Clin Biochem 2003;18(2):111–118. DOI: 10.1007/BF02867376.
Torkadi PP, Apte IC, Bhute AK. Biochemical Evaluation of Patients with Alcoholic Liver Disease and Non-alcoholic Liver Disease. IJCB 2014;29(1):79–83. DOI: 10.1007/s12291-013-0310-7.
Moulali D. A Study on Gamma Glutamyl Transferase and Amylase Levels in Chronic Alcoholics with Hepatitis. IJSRP 2015;5(11): 758–764.