Indian Journal of Medical Biochemistry

Register      Login

VOLUME 23 , ISSUE 3 ( September-December, 2019 ) > List of Articles

Original Article

Dyslipidemia in Patients with Acne Vulgaris: A Clinicobiochemical Study from a Tertiary Care Center

C Leelambika, Pushpa Sarkar

Keywords : Clinical biochemistry, Dyslipidemia, Triglyceride

Citation Information : Leelambika C, Sarkar P. Dyslipidemia in Patients with Acne Vulgaris: A Clinicobiochemical Study from a Tertiary Care Center. Indian J Med Biochem 2019; 23 (3):320-323.

DOI: 10.5005/jp-journals-10054-0112

License: CC BY-NC 4.0

Published Online: 01-06-2018

Copyright Statement:  Copyright © 2019; The Author(s).


Introduction: Acne vulgaris, a common dermatological disorder, is often associated with excess sebum production. Studies indicate acne and serum lipid profile pathophysiology and its association need further exploration. This study was done to evaluate the relationship and association between plasma lipid profile and acne. Materials and methods: A case–control study with group I containing 100 patients with acne vulgaris and group II containing 100 age- and gender-matched healthy volunteers as the control group. The lipid profile parameters were estimated in the cases and controls. Results: Serum total cholesterol, triglyceride, HDL, and LDL levels were measured. The predominant acne grade was grade II. Total cholesterol, triglyceride, and LDL levels were statistically higher than in the healthy control (significant with p < 0.05), whereas HDL level was insignificant. When lipid profiles between male and female were compared, there were no significant differences in both sexes between acne patients and controls. Total cholesterol, triglyceride, and LDL levels in patients with mild, moderate, and severe acne patients were statistically significant and correlated with the severity of acne. Conclusion: Acne patients are more frequently associated with altered lipid profile parameters, particularly with both moderate and severe acne. This deranged lipid parameters provide a new route for further exploration in the pathogenesis and also treatment aspects of acne vulgaris.

  1. Zaenglein AL, Graber EM, Thiboutut DM, et al. Acne vulgaris and Acneiform eruptions. In: Wolff K, Goldsmith LA, Katz SI, et al. ed. Fitzpatrick's dermatology in general medicine, 7th ed., New York: McGraw-Hill; 2008. pp. 690–700.
  2. Lucky AW, Biro FM, Huster GA, et al. Acne vulgaris in premenarchal girls. An early sign of puberty associated with rising levels of dehydroepiandrosterone. Arch Dermatol 1994;130:308–314. DOI: 10.1001/archderm.1994.01690030040006.
  3. Zouboulis CC. Acne and sebaceous gland function. Clin Dermatol 2004;22:360–366. DOI: 10.1016/j.clindermatol.2004.03.004.
  4. Cassidy DM, Lee CM, Laker MF, et al. Lipogenesis in isolated human sebaceous glands. FEBS Lett 1986;200:173–176. DOI: 10.1016/0014-5793(86)80533-6.
  5. Pochi PE. The pathogenesis and treatment of acne. Annu Rev Med 1990;41:187–198. DOI: 10.1146/
  6. Vergani C, Finzi AF, Pigatto PD, et al. Low level of HDL in severe cystic acne. N Engl J Med 1982;307:1151–1152.
  7. Arora MK, Seth S, Dayal S. The relationship of lipid profile and menstrual cycle with acne vulgaris. Clin Biochem 2010;43(18): 1415–1420. DOI: 10.1016/j.clinbiochem.2010.09.010.
  8. Pochi PE, Shalita AR, Strauss JS, et al. Report of the consensus conference on acne classification. J Am Acad Dermatol 1991;24: 495–500. DOI: 10.1016/S0190-9622(08)80076-X.
  9. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final port. Circulation 2002;106(25): 3143–3421.
  10. El-Akawi Z, Abdel-Latif N, Abdul-Razzak K, et al. The relationship between blood lipid profile and acne. J Health Sci 2007;53:596–599. DOI: 10.1248/jhs.53.596.
  11. Abulnaja KO. Changes in the harmone and lipid profile of obese adolescent Saudi females with acne vulgaris. Braz J Med Biol Res 2009;42:501–505. DOI: 10.1590/S0100-879X2009000600005.
  12. Strampfer MJ, Hu FB, Manson JE, et al. Primary prevention of coronary heart disease in women through diet and life style. N Engl J Med 2000;343:16–22. DOI: 10.1056/NEJM200007063430103.
  13. Kuller LH. Ethnic differences in atherosclerosis, cardiovascular diseases and lipid metabolism. Curr Opin Lipidol 2004;15:109–113. DOI: 10.1097/00041433-200404000-00003.
  14. Al-Shobaili HA. Oxidants and anti-oxidants status in acne vulgaris patients with varying severity. Ann Clin Lab Sci 2014;44(2): 202–207.
  15. Thiboutot DM, Strauss JS. Diet and acne revisited. Arch Dermatol 2002;138:1591–1592. DOI: 10.1001/archderm.138.12.1591.
  16. Jiang H, Li CY, Zhou L, et al. Acne patients frequently associated with abnormal plasma lipid profile. J Dermatol 2015;42:296–299. DOI: 10.1111/1346-8138.12761.
  17. George R, Clarke S, Thiboutot D. Hormonal therapy for acne. Semin Cutan Med Surg 2008;27:188–196. DOI: 10.1016/j.sder.2008. 06.002.
  18. Ekiz O, Balta I, Unlu E, et al. Assessment of thyroid function and lipid profile in patients with postadolescent acne in a Mediterranean population from turkey. Int J Dermatol 2015 Dec;54(12):1376–1381. DOI: 10.1111/ijd.12547.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.