Introduction: Acne vulgaris, a common dermatological disorder, is often associated with excess sebum production. Studies indicate acne and serum lipid profile pathophysiology and its association need further exploration. This study was done to evaluate the relationship and association between plasma lipid profile and acne.
Materials and methods: A case–control study with group I containing 100 patients with acne vulgaris and group II containing 100 age- and gender-matched healthy volunteers as the control group. The lipid profile parameters were estimated in the cases and controls.
Results: Serum total cholesterol, triglyceride, HDL, and LDL levels were measured. The predominant acne grade was grade II. Total cholesterol, triglyceride, and LDL levels were statistically higher than in the healthy control (significant with p < 0.05), whereas HDL level was insignificant. When lipid profiles between male and female were compared, there were no significant differences in both sexes between acne patients and controls. Total cholesterol, triglyceride, and LDL levels in patients with mild, moderate, and severe acne patients were statistically significant and correlated with the severity of acne.
Conclusion: Acne patients are more frequently associated with altered lipid profile parameters, particularly with both moderate and severe acne. This deranged lipid parameters provide a new route for further exploration in the pathogenesis and also treatment aspects of acne vulgaris.
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