Indian journal of Medical Biochemistry

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VOLUME 24 , ISSUE 2 ( May-August, 2020 ) > List of Articles

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Lymphocytes and Melatonin Interaction in COVID-19 and Serotonin Sepsis

Omkar K Choudhari, Anita Rani, Sonam Spalgais, Umesh C Ojha

Keywords : Inflammation, Melatonin, Serotonin,Cytokines

Citation Information : Choudhari OK, Rani A, Spalgais S, Ojha UC. Lymphocytes and Melatonin Interaction in COVID-19 and Serotonin Sepsis. Indian J Med Biochem 2020; 24 (2):81-82.

DOI: 10.5005/jp-journals-10054-0145

License: CC BY-NC 4.0

Published Online: 05-01-2021

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

The pandemic of SARS-CoV-2 has affected millions of lives worldwide. Many studies have described the cytokine storm and the subsequent shock behind acute respiratory distress syndrome. Melatonin, a hormone secreted by the pineal gland has excellent anti-inflammatory and immunomodulatory functions. Its role as an adjuvant in the treatment of COVID-19 has been described by many review studies. Serotonin is the intermediate product of melatonin and deficiency of intermediate enzymes causes serotonin surge increasing capillary permeability and shock.


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