Background: Competency-driven curriculum designed and implemented for MBBS from year 2019 comes with some unique features, and early clinical exposure (ECE) is one of them. Biochemistry is considered by students as a subject of metabolic pathways that are difficult to retain and recall when learned. In biochemistry, ECE helps to recognize importance of subject in diagnosis, patient care, and treatment. It will motivate student for active learning through its context and clinical case exposure. ECE allows students to learn basic science subject with its applicative perspective. Aim and objective: To study the effectiveness of ECE module of diabetes mellitus (DM) over didactic theory lecture in the understanding the disorder of carbohydrate metabolism. Materials and methods: The present interventional study was carried out in SKNMC, Pune, on 80 voluntary first-year MBBS students of academic year 2019 to 2020. Participants were evaluated with pretest and posttest questionnaire that was designed on DM keeping in mind the competencies given in the curriculum for the said topic. Statistical analysis was done using paired t test. Results: We have seen improved performance of students in posttest after ECE on DM as compared to pretest which was taken after traditional didactic lecture. Pretest and posttest score of students was 6.58 ± 2.86 (mean ± SD) and 12.36 ± 2.34, respectively. The p value for comparison was <0.001 which is highly significant. Conclusion: ECE for DM in biochemistry improved interest of students in the topic making learning more interactive.