Indian Journal of Medical Biochemistry

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VOLUME 25 , ISSUE 1 ( January-April, 2021 ) > List of Articles

Original Article

Serum Electrolytes in Subclinical Hypothyroidism and Subclinical Hyperthyroidism

Shraddha B Pattanashetti, Pratibha Krishnappa

Keywords : Chloride, Potassium, Subclinical hyperthyroidism, Subclinical hypothyroidism, Sodium

Citation Information : Pattanashetti SB, Krishnappa P. Serum Electrolytes in Subclinical Hypothyroidism and Subclinical Hyperthyroidism. Indian J Med Biochem 2021; 25 (1):1-4.

DOI: 10.5005/jp-journals-10054-0167

License: CC BY-NC 4.0

Published Online: 00-00-0000

Copyright Statement:  Copyright © 2021; The Author(s).


Background: Thyroid hormones have a central regulatory role in body hemodynamics, thermoregulation, and metabolism. The profound influence of thyroid hormones is observed on renal hemodynamics, glomerular filtration, renin-angiotensin-aldosterone system, and electrolyte balance. Thus, our main aim was to find out the electrolytes imbalance between subclinical hypothyroidism (SHO) and subclinical hyperthyroidism (SHE) and their correlation. Materials and methods: In our study, newly diagnosed 50 SHO and 35 SHE cases were selected. Blood samples were collected to analyze serum electrolytes (sodium, potassium, and chloride) by Electrolyte Analyzer from Roche. Mean, median, standard deviation, minimum value, maximum value, standard error of mean, and values at 95% confidence interval are calculated for the parameters. And the correlation between serum electrolytes with serum TSH was assessed. Results: There were no significant changes in levels of serum electrolytes in SHO and SHE, but the correlation between the levels of serum sodium and potassium with TSH showed little negativity or no changes in SHO and SHE, whereas the levels of serum chloride showed little positivity or no changes with TSH in SHO and little negativity or no changes with TSH in SHE. Conclusion: Hypothyroid and hyperthyroid patients in subclinical conditions will be having electrolyte imbalances and should be regularly checked for serum electrolytes. Also, electrolyte disturbances need to be monitored and treated appropriately to prevent further complications.

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  1. Murgod R, Amdsoans G. Changes in electrolyte and lipid profile in hypothyroidism. Int J Life Sci Pharma Res 2012;2(3):185–194. Rao GM. 1992. Serum electrolytes and osmolality in diabetes.
  2. Ismail BF, Edelman IS. The mechanism of the calorigenic effect of thyroid hormone stimulation of Na+ + K+ activated adenosinetri phosphatase activity. J Gen Physiol 1971;57(6):710. DOI: 10.1085/jgp.57.6.710.
  3. Abebe N, Kebede T, Wolde M. Assessment of renal function and electrolytes in patients with thyroid dysfunction in Addis Ababa, Ethiopia: a cross sectional study. Pan Afr Med J 2016;24:338. DOI: 10.11604/pamj.2016.24.338.8455.
  4. Abdel-Gayoum AA. Dyslipidemia and serum mineral profiles in patients with thyroid disorders. Saudi Med J 2014;35(12):1469–1472.
  5. Access 2 manual for Hybritech TSH from 2006 Beckman Coulter, Inc.
  6. Bharti A, Shrestha S, Rai R, et al. Assessment of serum minerals and electrolytes in thyroid patients. Int J Adv Sci Res 2015;1(06):259–263. DOI: 10.7439/ijasr.v1i6.2189.
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