Indian Journal of Medical Biochemistry

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VOLUME 25 , ISSUE 1 ( January-April, 2021 ) > List of Articles

REVIEW ARTICLE

Asthma in Relation to Coronary Heart Disease: A Systematic Review and Meta-analysis

Pallavi Mishra, Prashant Hisalkar, Neerja Mallick

Keywords : Asthma, Coronary heart disease, Inflammation, Meta-analysis, Systematic review

Citation Information : Mishra P, Hisalkar P, Mallick N. Asthma in Relation to Coronary Heart Disease: A Systematic Review and Meta-analysis. Indian J Med Biochem 2021; 25 (1):38-41.

DOI: 10.5005/jp-journals-10054-0176

License: CC BY-NC 4.0

Published Online: 00-04-2021

Copyright Statement:  Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim and background: Asthma is a clinical condition in which constriction of the airway occurs. It is a heterogeneous syndrome that manifesting different phenotypes. Coronary artery disease makes the arteries hardened and inflamed. Similarly, airway swelling occurs in asthma. Lipid accumulation and inflammation are the two common characteristics of coronary artery diseases. Therefore, many authors have described higher cardiovascular disease (CVD) risk in asthmatics. Materials and methods: The search strategy selected 10 published articles that were related to asthma and coronary artery disease and published from May 2004 to April 2018. Results: In this study, the pooled analysis indicated that asthma overall was significantly associated with CHD [OR 2.26 (1.45, 3.52), p = 0.0003]. The values for heterogeneity test were higher (I2 = 99%, p < 0.00001). Discussion: In this pooled analysis, we found that asthmatic patients have associated with a higher risk for coronary heart disease. Similarly, several previous studies also supported a positive association between asthma and the incidence of coronary heart disease.


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