Aim and objective: The goal of this study was to examine the association of high-sensitive C-reactive protein (hs-CRP) and lipid profile within 24 hours of onset of symptoms in acute coronary syndrome (ACS) patients.
Materials and methods: We studied 300 patients with ACS and 100 age- and sex-matched control subjects with no cardiac disease. Acute coronary syndrome patients were classified into two groups (I) onset of ACS symptoms <6 hours and (II) onset of ACS symptoms ≥6 and <24 h. Blood samples were obtained within 24 hours of hospital admission. High-sensitive C-reactive protein and lipid profile were analyzed by latex enhanced immunoturbidimetric method and enzymatic colorimetric methods, respectively.
Results: Overall serum levels of hs-CRP at the early phase of ACS were significantly higher (9.15 ± 5.89 vs 1.08 ± 0.7 mg/L, p < 0.001), along with altered lipid profile in patients than in control subjects. In subgroup analysis, serum concentrations of hs-CRP were approximately 3-fold higher in group I when compared with the control group (3.4 ± 2.08 vs 1.08 ± 0.7 mg/L, p < 0.001), and the levels of hs-CRP were almost 12-fold higher in group II than the controls (12.98 ± 4.26 vs 1.08 ± 0.7, p < 0.001). Between ACS patients subgroups, serum hs-CRP levels were almost 4-fold higher in group II when compared with group I (p < 0.001).
Conclusions: Our results demonstrate that hs-CRP is significantly higher in the patient's group during the early phase of ACS suggesting that inflammatory processes play a role in ACS.
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