Background: The coronavirus pandemic has affected all domains of our lives. Medical education is one such field that has been severely affected by disruptions in practical skill learning for which rapid adaptations were to be made. Closure of educational institutes to control the spread of the novel corona virus resulted in a drastic shift to the online teaching mode. A sparingly used modality in the developing countries. To continue medical education, our institute transitioned through various modes of E-learning, beginning with the e-enhancement mode, and ultimately moving toward the hybrid mode. Although we were off to an erratic start, as time progressed, events began to proceed smoothly as the students and faculty adjusted to the new normal which continues to date. In this article, we share our experience as we transitioned through the various modes of E-learning. Conclusion: E-learning has always played an important role in medical education. In the pre-COVID era, e-enhancement was already in use, but in a limited way, while during the peak of the pandemic, the online mode became indispensable. When the medical college re-opened and the physical presence of the students was now possible, the hybrid mode was predominant, i.e., there were in-person interactions between teachers and students, along with the continuation of other online components. This ensured that COVID norms were followed such as the maintenance of physical distancing, along with the continuous implementation of the curriculum of medical education.