Indian Journal of Medical Biochemistry

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VOLUME 25 , ISSUE 3 ( September-December, 2021 ) > List of Articles


Establishing Umbilical Cord Thyroid-stimulating Hormone in Neonates at a Tertiary Care Teaching Hospital for Screening Congenital Hypothyroidism

Annapurna V Raichurkar, Rahul Jahagirdar, Meghana K Padwal, Minal M Pore

Keywords : Chemiluminescent microparticle immunoassay, Congenital hypothyroidism, Neonates, Umbilical cord thyroid-stimulating hormone

Citation Information : Raichurkar AV, Jahagirdar R, Padwal MK, Pore MM. Establishing Umbilical Cord Thyroid-stimulating Hormone in Neonates at a Tertiary Care Teaching Hospital for Screening Congenital Hypothyroidism. Indian J Med Biochem 2021; 25 (3):121-124.

DOI: 10.5005/jp-journals-10054-0190

License: CC BY-NC 4.0

Published Online: 11-03-2022

Copyright Statement:  Copyright © 2021; The Author(s).


Aim: To find the normative value of cord thyroid-stimulating hormone (TSH) in neonates in our study group for screening congenital hypothyroidism (CH). Objectives: 1. To establish the cutoff level of cord TSH in full-term and preterm neonates. 2. Correlate cord TSH value with birth weight, gender, and gestational age. Materials and methods: A prospective study was conducted in tertiary care hospital for a period of 1 year from 1st February 2019 to 31st January 2020. Umbilical cord blood (3 mL) collected in sterile vacutainer under aseptic precaution, at the time of delivery from the maternal end of cord and TSH was estimated by chemiluminescent microparticle immunoassay (CMIA) technique. This study was carried out on 1,357 neonates. All data were collected prospectively. Mothers with thyroid illness and/or thyroid medication were excluded from the study. Results: Umbilical cord TSH sample was tested on all 1,357 babies delivered in tertiary hospitals for a period of 1 year. Seven hundred and fifty were males (55.2%) and 607 were females (44.7%). One thousand and sixteen were normal term (74.8%) babies. The mean, median, and standard deviation of cord TSH values were 6.8, 5.5, and 4.5, respectively, in term neonates. Thyroid-stimulating hormone value corresponding to 90th, 95th, and 97th percentile was 16.5, 18.9, and 24.8 percentile in term neonates. Cord TSH values of >20 mIU/L were found in 30 (2.2%) neonates. One neonate had persistently higher TSH on repeat testing. There was no significant correlation of cord TSH between birth weight and gender of neonates but we found a significant correlation of gestational age with cord TSH value (p value < 0.05). Conclusion: Incidence of CH was 1 in 1,357 in our study. Umbilical cord TSH is a significant investigation for screening CH and a cutoff of >20 mIU/L can be used for screening CH.

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