Indian Journal of Medical Biochemistry

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VOLUME 26 , ISSUE 1 ( January-April, 2022 ) > List of Articles

REVIEW ARTICLE

NGAL: An Upcoming Biomarker of Interest

Khushboo Jasotani, Kiran Dahiya, Raunak Ahlawat, Mohit Gupta, Sushil Kumar, Rakesh Dhankhar, Pragati Singh

Keywords : Biomarker, Diseases, Neutrophil gelatinase-associated lipocalin, Lipocalins

Citation Information : Jasotani K, Dahiya K, Ahlawat R, Gupta M, Kumar S, Dhankhar R, Singh P. NGAL: An Upcoming Biomarker of Interest. Indian J Med Biochem 2022; 26 (1):26-30.

DOI: 10.5005/jp-journals-10054-0206

License: CC BY-NC 4.0

Published Online: 03-01-2023

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

Aim: Neutrophil gelatinase-associated lipocalin (NGAL) performs important functions in the body. It has the potential to act as a diagnostic and prognostic biomarker for various diseases. Background: The role of NGAL has been well explored in acute and chronic kidney diseases (CKDs). It is considered a maker for acute kidney injury (AKI). Its role in other diseases has also been increasingly reported. Results: Neutrophil gelatinase-associated lipocalin takes part in the pathogenesis of several diseases, besides renal diseases, like cardiovascular diseases, inflammatory disorders, cancer, diabetes, etc. by a variety of mechanisms. Its levels have been correlated with the severity in most of the diseases. Conclusion: Neutrophil gelatinase-associated lipocalin can act as a biomarker in different diseases though, its potential is yet to be explored to the maximum. Clinical significance: Estimating the levels of NGAL in body fluids will help in making an early diagnosis, assessing the severity of the disease, establishing a prognosis, and improving the overall management of different diseases.


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