Indian Journal of Medical Biochemistry

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VOLUME 27 , ISSUE 1 ( January-April, 2023 ) > List of Articles

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Atherogenic Index of Plasma in Acute Coronary Syndrome: An Observational Study in a Tertiary Care Hospital

Surya Kantha Bugge

Keywords : Acute coronary syndrome, Atherogenic index of plasma, Coronary artery disease, High-density lipoprotein, Low-density lipoprotein, Triglycerides

Citation Information : Bugge SK. Atherogenic Index of Plasma in Acute Coronary Syndrome: An Observational Study in a Tertiary Care Hospital. Indian J Med Biochem 2023; 27 (1):14-17.

DOI: 10.5005/jp-journals-10054-0214

License: CC BY-NC 4.0

Published Online: 07-12-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Abstract

Atherogenic index of plasma (AIP) is a log of triglyceride (TG) to high-density lipoprotein (HDL) ratio in mmoL/L is a surrogate marker of lipoprotein size of low-density lipoprotein and HDL, smaller the size, greater the atherogenicity. Materials and methods: A total of 102 participants with acute coronary syndrome (ACS) and 90 non-coronary artery disease (CAD) asymptomatic participants, not on lipid reduction, were consequently observed and the traditional risk factors and lipidogram were noted and AIP was calculated from the lipidograms. Results: Atherogenic index of plasma values was considerably higher in patients with ACS than in Non-CAD patients p < 0.00001 and was raised in the male gender p < 0.01. Discussion: Atherogenic index of plasma used as a predictive and prognostic marker in CAD, ischemic stroke, metabolic syndrome it's been studied that higher the AIP, higher the angiographically proven lesions according to the Gensen score. Conclusion: Atherogenic index of plasma is an economical and novel biomarker of atherogenicity.


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  1. Liu H, Liu K, Pei L, et al. Atherogenic index of plasma predicts outcomes in acute ischemic stroke. Front Neurol 2021;12:741754. DOI: https://doi.org/10.3389/fneur.2021.741754.
  2. Frohlich J, Dobiášová M. Fractional esterification rate of cholesterol and ratio of triglycerides to HDL-Cholesterol are powerful predictors of positive findings on coronary angiography. Clin Chem 2003;49(11):1873–1880. DOI: 10.1373/clinchem.2003.022558.
  3. Dobiásová M, Frohlich J. The plasma parameter log (TG/HDL-C) as an atherogenic index: Correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL)). Clin Biochem 2001;34(7):583–588. DOI: 10.1016/s0009-9120(01)00263-6.
  4. Dobiásová M. AIP–aterogenní index plazmy jako významný prediktor kardiovaskulárního rizika: od výzkumu do praxe [AIP–atherogenic index of plasma as a significant predictor of cardiovascular risk: From research to practice]. Vnitr Lek 2006;52(1):64–71. Czech. PMID: 16526201.
  5. Amrita J, Mahajan M, Bhanwer A J, et al. Oxidative stress: An effective prognostic tool for an early detection of cardiovascular disease in menopausal women. Biochem Res Int 2016;2016:6157605. DOI: https://doi.org/10.1155/2016/6157605.
  6. Bakshi A, Bavikar J, Asegaonkar S. Comparative study of calculated lipid indices viz atherogenic index of plasma, atherogenic coefficient and lipid accumulation product over conventional lipid profile parameters as better predictors of atherosclerosis in obesity: A cross sectional study. Int J Clin Biochem Res 2019;6(1):2–6. DOI: https://doi.org/10.18231/2394-6377.2019.0002.
  7. Li YW, Kao TW, Chang PK, et al. Atherogenic index of plasma as predictors for metabolic syndrome, hypertension and diabetes mellitus in Taiwan citizens: A 9-year longitudinal study. Sci Rep 2021;11(1):9900. DOI: https://doi.org/10.1038/s41598-021-89307-z.
  8. Shui X, Chen Z, Wen Z, et al. Association of atherogenic index of plasma with angiographic progression in patients with suspected coronary artery disease. Angiology 2022;73(10):927–935. DOI: https://doi.org/10.1177/00033197221080911.
  9. Kim JJ, Yoon J, Lee YJ, et al. Predictive value of the atherogenic index of plasma (AIP) for the risk of incident ischemic heart disease among non-diabetic Koreans. Nutrients 2021;13(9):3231. DOI: https://doi.org/10.3390/nu13093231.
  10. Kim SH, Cho YK, Kim YJ, et al. Association of the atherogenic index of plasma with cardiovascular risk beyond the traditional risk factors: A nationwide population-based cohort study. Cardiovasc Diabetol 2022;21(1):81. DOI: https://doi.org/10.1186/s12933-022-01522-8.
  11. Shi Y, Wen M. Sex-specific differences in the effect of the atherogenic index of plasma on prediabetes and diabetes in the NHANES 2011–2018 population. Cardiovascular Diabetology 2023;22(1):19. DOI: https://doi.org/10.1186/S12933-023-01740-8.
  12. Li Y, Feng Y, Li S, et al. The atherogenic index of plasma (AIP) is a predictor for the severity of coronary artery disease. Front Cardiovasc Med 2023;10:1140215. DOI: https://doi.org/10.3389/fcvm.2023.1140215.
  13. Cai G, Liu W, Lv S, et al. Gender-specific associations between atherogenic index of plasma and the presence and severity of acute coronary syndrome in very young adults: A hospital-based observational study. Lipids Health Dis 2019;18(1):99. DOI: https://doi.org/10.1186/s12944-019-1043-2.
  14. Ma X, Sun Y, Cheng Y, et al. Prognostic impact of the atherogenic index of plasma in type 2 diabetes mellitus patients with acute coronary syndrome undergoing percutaneous coronary intervention. Lipids in health and disease 2020;19(1):240. DOI: https://doi.org/10.1186/s12944-020-01418-0.
  15. Huang Q, Liu Z, Wei M, et al. The atherogenic index of plasma and carotid atherosclerosis in a community population: A population-based cohort study in China. Cardiovasc Diabetol 2023;22(1):125. DOI: https://doi.org/10.1186/s12933-023-01839-y.
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