Introduction: Infertility is one of the major health concerns among women of reproductive age group. Food habits and sedentary life style has lead to obesity among young women. With obesity, the incidence of infertility is on the raise in the last decade. Imbalance of sex hormones like FSH, LH, prolactin, estrogen, progesterone and testosterone contributes to the female infertility. Obesity also plays a significant role on reproductive system contributing to female infertility. The adipokines secreted from adipose tissue also to be evaluated to understand its role on infertility. Adipokines, like adiponectin, leptin, resistin and visfatin secreted from adipocytes, influence the reproductive organs via various mechanisms. So it is essential to evaluate the adipokines and sex hormones for better understanding of infertility and hence help in the treatment of infertility. Aim: To estimate the levels of fasting blood sugar, triglyceride, total cholesterol, HDL, LDL, VLDL, insulin, insulin resistance, FSH, LH, testosterone, prolactin, leptin, adiponectin, visfatin and resistin among infertile women and compare with fertile women of reproductive age group. Materials and methods: Fifty women with unexplained infertility were included as cases and fifty fertile women in reproductive age were included as controls. Results: BMI, waist/hip ratio, insulin, insulin resistance was significantly high in cases than controls. FSH, LH, prolactin, testosterone was high in cases compared to controls. Adiponectin was low in cases than controls, whereas leptin, visfatin and resistin was high in cases than controls. Conclusion: Sex hormones have influence on adipokines indicating role of adipokines in infertility.