The pandemic of SARS-CoV-2 has affected millions of lives worldwide. Many studies have described the cytokine storm and the subsequent shock behind acute respiratory distress syndrome. Melatonin, a hormone secreted by the pineal gland has excellent anti-inflammatory and immunomodulatory functions. Its role as an adjuvant in the treatment of COVID-19 has been described by many review studies. Serotonin is the intermediate product of melatonin and deficiency of intermediate enzymes causes serotonin surge increasing capillary permeability and shock.
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