Indian Journal of Medical Biochemistry

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VOLUME 22 , ISSUE 1 ( January-June, 2018 ) > List of Articles

ORIGINAL ARTICLE

Cerebrospinal Fluid Bioprofiling

Mala Malathi, Shailaja A Katti

Keywords : Aspartate transaminase, Cerebrospinal fluid, Cerebrospinal fluid C-reactive protein, Cerebrospinal fluid lactate dehydrogenase

Citation Information : Malathi M, Katti SA. Cerebrospinal Fluid Bioprofiling. Indian J Med Biochem 2018; 22 (1):47-49.

DOI: 10.5005/jp-journals-10054-0053

License: CC BY-NC 3.0

Published Online: 01-06-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Introduction: Meningitis is one of the most serious health issues. The World Health Organization (WHO) defines as inflammation of the meninges, the covering of brain, and spinal cord. Most common cause is by infection. It is always reported with very aggressive and devastating outcome on health and continues to cause significant morbidity and mortality worldwide. The current study is focused on bioprofiling of cerebrospinal fluid (CSF) which can be aided for early diagnosis of meningitis and helpful for differentiating meningitis from nonmeningitis for deciding treatment regimen by the treating clinician. Objective: To study the biochemical parameters in meningitis patients and compare CSF bioprofile. Materials and methods: It is an observational analytical study with a total of 60 subjects aged between 18 and 60 years, conducted in Father Muller Medical College Hospital, Mangaluru, for a duration of 3 months, after obtaining clearance from the institutional ethics committee. The samples sent for the analysis to the clinical biochemistry laboratory were collected and the same were used for the study after obtaining the informed consent from the patient. The traumatic samples and systemic disorder patient samples were excluded form the study. The parameters analyzed were: CSF C-reactive protein (CRP), CSF electrolytes, CSF aspartate transaminase (AST), and CSF lactate dehydrogenase (LDH) apart from the routine CSF protein and glucose in both group I (meningitis) and group II (nonmeningitis). Results: The statistical analysis was performed using the Statistical Package for the Social Sciences (SPSS) version 23, with the significance value of 0.05. The mean of the CSF CRP was 2.0 ± 1.12 in group I compared with group II 0.09 ± 0.15; CSF AST was 17.42 ± 6.24, 5.1 ± 3.8 in groups I and II respectively; and CSF LDH was 211.1 ± 49.0, 23.71 ± 10.29 in groups I and II respectively, with p-value < 0.001 (highly significant). Conclusion: The CSF CRP was found to be increased in patients with meningitis compared with the negative CSF, and the significant increase in the CSF AST and LDH; this knowledge can help to aid the routine CSF protein and glucose to differentiate the meningitis before the result of the culture is reported for deciding the treatment regimen.


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  1. Babiker MA, Taha SA. Meningitis in children of Riyadh. J Trop Med Hyg 1984 Dec;87(6):245-248.
  2. WHO. WHO meningitis. Geneva: WHO; 2015. [cited 2015 Dec 21]. Available from: http://www.who.int/topics/ meningitis/en/.
  3. Aronin SI, Peduzzi P, Quagliarello VJ. Community-acquired bacterial meningitis: risk stratification for adverse clinical outcome and effect of antibiotic timing. Ann Intern Med 1998 Dec;129(11):862-869.
  4. Rajnik M, Ottolni MG. Serious infections of central nervous system: encephalitis, meningitis and brain abscess. Adolesc Med 2000 Jun;11(2):401-425.
  5. Thomas KE, Hasbun R, Jekel J, Quagliarello VJ. The diagnostic accuracy of Kernig's sign, Brudzinski's sign and nuchal rigidity in adults with suspected meningitis. Clin Infect Dis 2002 Jul;35(1):46-52.
  6. Snyder RD. Bacterial meningitis: diagnosis and treatment. Curr Neurol Neurosci Rep 2003 Nov;3(6):461-469.
  7. Sormunen P, Kallio MJ, Kilpi T, Peltola H. C-reactive protein is useful in distinguishing Gram stain-negative bacterial meningitis from viral meningitis in children. J Pediatr 1999 Jun;134(6):725-729.
  8. Jadali F, Sharifi M, Jarollahi A, Nahidi S. C-reactive protein and lactate dehydrogenase in serum and cerebrospinal fluid in rapid and early diagnosis of childhood meningitis. Iran J Child Neurol 2009;1(4):37-46.
  9. Rekha S, Sarada U, Venkateswarlu U, Reddi Naresh P. Study of biochemical profile in viral meningitis. IOSR J Dent Med Sci 2015 Mar;14(3):45-47.
  10. Vanderlelie JJ. Improving the student experience of learning and teaching in second year biochemistry: Assessment to foster a creative application of biochemical concepts. Int J Innov Sci Math Educ 2013;21(4):46-57.
  11. Wilma DS, Suresh DR, Chandrakala MV. Evaluation of small group discussion as a teaching-learning method in biochemistry for first year MBBS students: a pilot study. South East Asian J Med Educ 2014;8(2):43-47.
  12. Kulak V, Newton G. A guide to using case-based learning in biochemistry education. Biochem Mol Biol Educ 2014 Nov-Dec;42(6):457-473.
  13. Chapman DM, Calhoun JG. Validation of learning style measures: implications for medical education practice. Med Educ 2006 Jun;40(6):576-583.
  14. Ojennus DD. Assessment of learning gains in a flipped biochemistry classroom. Biochem Mol Biol Educ 2016 Jan-Feb;44(1):20-27.
  15. Higashi T, Ichikawa T, Shimizu C, Nagai S, Inagaki S, Min JZ, Chiba H, Ikegawa S, Toyo'oka T. Stable isotope-dilution liquid chromatography/tandem mass spectrometry method for determination of thyroxine in saliva. J Chromatogr B Analyt Technol Biomed Life Sci 2011 Apr;879(13-14):1013-1017.
  16. Vining RF, McGinley RA, Symons RG. Hormones in saliva: mode of entry and consequent implications for clinical interpretation. Clin Chem 1983 Oct;29(10):1752-1756.
  17. Tanaka K, Imura H. Iodothyronine 5’-deiodinase is present in mouse sublingual gland. Endocrinology 1993 Mar;132(3): 1195-1198.
  18. Altman DG, Bland JM. Measurement in medicine: the analysis of method comparison studies. Statistician 1983 Sep;32(3): 307-317.
  19. Hallman M, Teramo K. Measurement of the lecithin/sphingomyelin ratio and phosphatidylglycerol in amniotic fluid: an accurate method for the assessment of fetal lung maturity. Br J Obstet Gynaecol 1981 Aug;88(8):806-813.
  20. Weeke J, Gundersen HJ. Circadian and 30 minutes variations in serum TSH and thyroid hormones in normal subjects. Acta Endocrinol (Copenh) 1978 Dec;89(4):659-672.
  21. Jensen E, Blaabjerg O, Petersen PH, Hegedüs L. Sampling time is important but may be overlooked in establishment and use of thyroid-stimulating hormone reference intervals. Clin Chem 2007 Feb;53(2):355-356.
  22. Den Heijer M, Koster T, Blom HJ, Bos GM, Briet E, Reitsma PH, Vandenbroucke JP, Rosendaal FR. Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. N Engl J Med 1996 Mar;334(12):759-762.
  23. Hoogeveen EK, Kostense PJ, Beks PJ, Mackaay AJ, Jakobs C, Bouter LM, Heine RJ, Stehouwer CD. Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease, especially in non-insulin-dependent diabetes mellitus: a population-based study. Arterioscler Thromb Vasc Biol 1998;18:133-138.
  24. Okada E, Oida K, Tada H, Asazuma K, Eguchi K, Tohda G, Kosada S, Takahashi S, Miyamori I. Hyperhomocysteinemia is a risk factor for coronary arteriosclerosis in Japanese patients with type 2 diabetes. Diabetes Care 1999 May;22(3):484-490.
  25. Smulders YM, Rakic M, Slaats EH, Treskes M, Sijbrands EJ, Odekerken DA, Stehouwer CD, Silberbusch J. Fasting and post-methionine homocysteine levels in NIDDM: determinants and correlations with retinopathy, albuminuria, and cardiovascular disease. Diabetes Care 1999 Jan;22(1): 125-132.
  26. Agardh CD, Agardh E, Andersson A, Hultberg B. Lack of association between plasma homocysteine levels and microangiopathy in type 1 diabetes mellitus. Scand J Clin Lab Invest 1998 Dec;54(8):637-641.
  27. Chico A, Perez A, Cordoba A, Arcelus R, Carreras G, de Leiva A, Gonzalez-Sastre F, Blanco-Vaca F. Plasma homocysteine is related to albumin excretion rate in patients with diabetes mellitus: a new link between diabetic nephropathy and cardiovascular disease? Diabetologia 1998 Jun;41(6):684-693.
  28. Wollesen F, Brattstrom L, Refsum H, Ueland PM, Berglund L, Berne C. Plasma total homocysteine and cysteine in relation to glomerular filtration rate in diabetes mellitus. Kidney Int 1999 Mar;55(3):1028-1035.
  29. Stabler S, Estacio R, Jeffers B, Cohen J, Allen R, Schrier R. Total homocysteine is associated with nephropathy in non-insulindependent diabetes mellitus. Metabolism 1999 Sep;48(9): 1096-1101.
  30. Puri A, Gupta OK, Dwivedi RN, Bharadwaj RPS, Na-rain VS, Singh S. Homocysteine and lipid levels in young patients with coronary artery disease. J Assoc Phys India 2003 Jul;51:681-685.
  31. Abraham JM, Cho L. The homocysteine hypothesis: still relevant to the prevention and treatment of cardiovascular disease? Cleve Clin J Med 2010 Dec;77(12):911-918.
  32. Samia J, Asghar S, Fayaz. Relation of high density lipoprotein cholesterol concentration to type of diabetes and its control. Biomedica 2000;16:19-24.
  33. Krauss RM. Lipids and lipoproteins in patients with type 2 diabetes. Diabetes Care 2004 Jun;27(6):1496-1504.
  34. Ronald M. Lipid and lipoproteins in type 2 diabetes. Diabetes Care 2004 Jun;27(6):1496-1504.
  35. Tushuizen M, Diamant M, Heine R. Postprandial dysmetabolism and cardiovascular disease in type 2 diabetes. Postgrad Med J 2005 Jan;81(951):1-6.
  36. Shera A, Jawad F. Prevalence of chronic complications and associated factors in Type 2 Diabetes. J Pak Med Assoc 2004 Feb;54(2):54-59.
  37. Alakailly X, Kummoona R, Quereshy FA, Baur DA, Gonzalez AE. The use of sodium tetradecyl sulphate for the treatment of venous malformations of the head and neck. J Maxillofac Oral Surg 2015 Jun;14(2):332-338.
  38. Yamaki T, Nozaki M, Sakurai H, Takeuchi M, Soejima K, Kono T. Prospective randomized efficacy of ultrasound-guided foam sclerotherapy compared with ultrasound-guided liquid sclerotherapy in the treatment of symptomatic venous malformations. J Vasc Surg 2008 Mar;47(3):578-584.
  39. Imbesi SG, Green DA, Cho A, Pakbaz RS. MR angiographicguided percutaneous sclerotherapy for venous vascular malformations: a radiation dose-reduction strategy. AJNR Am J Neuroradiol 2016 Feb;37(2):205-209.
  40. Muir T, Kirsten M, Fourie P, Dippennar N, Ionescu GO. Interalesional bleomycin injection (IBI) treatment for haemangiomas and congenital vascular malformations. Pediatr Surg Int 2004 Jan;19(12):766-773.
  41. Spence J, Krings T, terBrugge KG, da Costa LB, Agid R. Percutaneous sclerotherapy for facial venous malformations: subjective clinical and objective MR imaging follow-up results. AJNR Am J Neuroradiol 2010 May;31(5):955-960.
  42. Folayan M, Owotade F, Adejuyigbe E, Sen S, Lawal B, Ndukwe K. The timing of eruption of the primary dentition in Nigerian children. Am J Phys Anthopol 2007 Dec;134(4): 443-448.
  43. Feraru IV, Raducanu AM, Feraru SM, Herteliu C. The sequence and chronology of the eruption of permanent canines and premolars in a group of Romanian children in Bucharest. OHMD 2011;10(4):193-198.
  44. Singh S, Sharma A, Sandhu N, Mehta K. The prevalence of malocclusion and orthodontic treatment needs in school going children of Nalagarh, Himachal Pradesh, India. Indian J Dent Res 2016 May-Jun;27(3):317-322.
  45. Amado JN, Sierraa AM, Gallon A, Alvarez C, Baccettic T. Relationship between personality traits and cooperation of adolescent orthodontic patients. Angle Orthod 2008 Jul;78(4):688-691.
  46. Ansai T, Miyazaki H, Katoh Y, Yamashita Y, Takehara T, Jenny J, Cons NC. Prevalence of malocclusion in high school students in Japan according to the dental aesthetic index. Comm Dent Oral Epidemiolol 1993 Oct;21(5):303-305.
  47. Danaei SM, Amirrad F, Salehi P. Orthodontic treatment needs of 12- 15 year old students in Shiraz, Islamic Republic of Iran. East Mediterr Health J 2007 Mar-Apr;13(2):326-334.
  48. Onyeaso CO, BeGole EA, Orthodontic treatment need in an accredited orthodontic centre in North America: a pilot study. J Contemp Dent Pract 2006 May;7(2):87-94.
  49. Onyeaso CO, Sanu OO. Perception of personal dental appearance in Nigeria adolescents. Am J Orthod Dentofac Orthop 2005 Jun;127(6):700-706.
  50. Onyeaso CO. Orthodontic concern of parents compared with orthodontic treatment need assessed by Dental Aesthetic Index (DAI) in Ibaden, Nigeria. Odontostomatol Trop 2003 Mar;26(101):13-20.
  51. Naveen Kumar B, Mohapatra A, Ramesh N, Ravishankar TL. Prevalence of malocclusion and orthodontic treatment need among 12-15 years old school children in Davangere, Karnataka, India. Pak Oral Dent J 2010;30(1):181-185.
  52. de Oliveira CM, Sheiham A. The relationship between normative orthodontic treatment need and oral health-related quality of life. Community Dent Oral Epidemiol 2003 Dec;31(6):426-436.
  53. de Oliveira CM, Sheiham A, Tsakos G, O'Brien KD. Oral health related quality of life and the IOTN index as predictors of children's perceived needs and acceptance for orthodontic treatment. Br Dent J 2008 Apr;204(7):1-5.
  54. Al-Sarheed M, Bedi R, Hunt NP. Orthodontic treatment need and self perception of 11-16 year old Saudi Arabian children with a sensory impairment attending special schools. J Orthod 2003 Mar;30(1):39-44.
  55. Kerosuo H, Al Enezi S, Kerosuo E, Abdulkarim E. Association between normative and self perceived orthodontic treatment need among Arab high school students. Am J Orthod Dentofacial Orthop 2004 Mar;125(3):373-378.
  56. Ghijselings I, Brosens V, Williams G, Fieuws S, Clijmans M, Lemiere J. Normative and self-perceived orthodontic treatment need in 11- to 16-year-old children. Eur J Orthod 2014 Apr;36(2):179-185.
  57. Onyeaso CO, Arowojolu MO. Perceived, desired and normatively determined treatment need among orthodontically untreated Nigerian adolescents. West Afr J Med 2003 Jan- Mar;22(1):5-9.
  58. Jung MH. Quality of life and self-esteem of female orthognathic surgery patients. J Oral Maxillofac Surg 2016 Jun;74(6):1240.e1-1240.e7.
  59. Abu Alhaija ES, Al-Nimri KS, Al-Khateeb SN. Self perception of malocclusion among Jordanian school children. Eur J Orthod 2005 Jun;27(3):292-295.
  60. Kolawole KA, Otuyemi DE, Jebode SO, Unweni AA. Awareness for malocclusion and desire for orthodontic treatment need in 11-14year old Nigerian school and their parents. Aust Orthod J 2008 May;24(1):21-25.
  61. Cucalon A 3rd, Smith RJ. Relationship between by adolescent orthodontics patients and performance on psychological tests. Angle Orthod 1990 Summer;60(2):107-114.
  62. Southard KA, Tolley EA, Arheart KL, Hackett-Renner CA, Southard TE. Application of the Millon Adolescent Personality Inventory in evaluating orthodontic compliance. Am J Orthod Dentofacial Orthop 1991 Dec;100(6):553-561.
  63. Kharbanda OP. What is the prevalence of malocclusion in India? Do we know orthodontic treatment needs of our country. J Indian Orthod Soc 1999 Apr-Jun;32(2):33-41.
  64. Siddiqui TA, Shaikh A, Fida M. Agreement between orthodontist and patient perception using Index of Orthodontic Treatment Need. Saudi Dent J 2014 Oct;26(4):156-165.
  65. Borzabadi-Farahani A, Borzabadi-Farahani A, Eslamipour F. Orthodontic treatment needs in an urban Iranian population in epidemiological study of 11-14 years old children. Eur J Paediatr Dent 2009 Jun;10(2):69-74.
  66. Grando G, Young AA, Vedovello Filho M, Vedovello SA, Ramirez-Yañez GO. Prevalence of malocclusions in a young Brazilian population. Int J Orthod Milwaukee 2008 Summer;19(2):13-16.
  67. Nadim R, Aslam K, Rizwan S. Frequency of malocclusion among 12 -15 years old school children in three sectors of Karachi. Pak Oral Dent J 2014 Sep;34(3):510-514.
  68. Reddy ER, Manjula M, Sreelakshmi N, Rani ST, Aduri R, Patil BD. Prevalence of malocclusion among 6 to 10 year old Nalgonda school children. J Int Oral Health 2013 Dec;5(6): 49-54.
  69. Onyeaso CO. Prevalence of malocclusion among adolescents in Ibadan, Nigeria. Am J Orthod Dentofacial Orthop 2004 Nov;126(5):604-607.
  70. Kaur H, Pavithra US, Abraham R. Prevalence of malocclusion among adolescents in South Indian population. J Int Soc Prev Community Dent 2013 Jul-Dec;3(2):97-102.
  71. Lauc T. Orofacial analysis on the Adriatic islands: an epidemiological study of malocclusions on Hvar Island. Eur J Orthod 2003 Jun;25(3):273-278.
  72. Zimmermann E, Gamborg M, Holst C, Baker JL, Sørensen TI, Berentzen TL. Body mass index in school-aged children and the risk of routinely diagnosed non-alcoholic fatty liver disease in adulthood: a prospective study based on the Copenhagen School Health Records Register. BMJ Open 2015 May;5(4):e006998.
  73. Singh SP. Non-alcoholic fatty liver disease: the unfolding monster? J Gastroenterol Hepatol 2006 Jan;21(1 Pt 2):199-201.
  74. Reece EA, Hagay Z, Roberts AB, DeGennaro N, Homko CJ, Connolly-Diamond M, Sherwin R, Tamborlane WV, Diamond MP. Fetal Doppler and behavioral responses during hypoglycemia induced with the insulin clamp technique in pregnant diabetic women. Am J Obstet Gynecol 1995 Jan;172(1 Pt 1):151-155.
  75. Patrick J, Campbell K, Carmichael L, Natale R, Richardson B. Patterns of gross fetal body movements over 24-hour observation intervals during the last 10 weeks of pregnancy. Am J Obstet Gynecol 1982 Feb;142(4):363-371.
  76. Ornoy A, Ratzon N, Greenbaum C, Peretz E, Soriano D, Dulitzky M. Neurobehavior of school age children born to diabetic mothers. Arch Dis Child Fetal Neonatal Ed 1998 Sep;79(2):F94-F99.
  77. Wolf, A. Developmental evaluation on early school age children born to gestational diabetic mothers. Israel: Hebrew University; 1997.
  78. Mulder EJ, Leiblum DM, Visser GH. Fetal breathing movements in late diabetic pregnancy: relationship to fetal heart rate patterns and Braxton Hicks’ contractions. Early Hum Dev 1995 Nov;43(3):225-232.
  79. Schulte FJ, Michaelis R, Nolte R, Albert G, Parl U, Lasson U. Brain and behavioral maturation in newborn infants of diabetic mothers. I. Nerve conduction and EEG patterns. Neuropadiatrie 1969 Jan-Jul;1(1):24-35.
  80. Devoe LD, Youssef AA, Castillo RA, Croom CS. Fetal biophysical activities in third-trimester pregnancies complicated by diabetes mellitus. Am J Obstet Gynecol 1994 Aug;171(2):298-303.
  81. Dierker LJ Jr, Pillay S, Sorokin Y, Rosen MG. The change in fetal activity periods in diabetic and nondiabetic pregnancies. Am J Obstet Gynecol 1982 May;143(2):181-185.
  82. Doherty NN, Hepper PG. Habituation in fetuses of diabetic mothers. Early Hum Dev 2000 Aug;59(2):85-93.
  83. Kainer F, Prechtl HF, Engele H, Einspieler C. Assessment of the quality of general movements in fetuses and infants of women with type-1 diabetes mellitus. Early Hum Dev 1997 Nov;50(1):13-25.
  84. Mulder EJ, O'Brien MJ, Lems YL, Visser GH, Prechtl HF. Body and breathing movements in near-term fetuses and newborn infants of type-1 diabetic women. Early Hum Dev 1990 Nov;24(2):131-152.
  85. Mulder EJ, Visser GH. Growth and motor development in fetuses of women with type-1 diabetes. I. Early growth patterns. Early Hum Dev 1991 May;25(2):91-106.
  86. Mulder EJ, Visser GH. Growth and motor development in fetuses of women with type-1 diabetes. II. Emergence of specific movement patterns. Early Hum Dev 1991 May;25(2):107-115.
  87. Mulder EJ, Visser GH. Impact of early growth delay on subsequent fetal growth and functional development: a study on diabetic pregnancy. Early Hum Dev 1992 Dec;31(2):91-95.
  88. Mulder EJ, Visser GH, Bekedam DJ, Prechtl HF. Emergence of behavioral states in fetuses of type-1 diabetic women. Early Hum Dev 1987 Jul;15(4):231-251.
  89. Mulder EJ, Visser GH, Morssink LP, de Vries JI. Growth and motor development in fetuses of women with type-1 diabetes. III. First trimester quantity of fetal movement patterns. Early Hum Dev 1991 May;25(2):117-133.
  90. Aberg A, Westbom L, Kallen B. Congenital malformations among infants whose mothers had gestational diabetes or preexisting diabetes. Early Hum Dev 2001 Mar;61(2):85-95.
  91. Deregnier RA, Nelson CA, Thomas KM, Wewerka S, Georgieff MK. Neurophysiologic evaluation of auditory recognition memory in healthy newborn infants and infants of diabetic mothers. J Pediatr 2000 Dec;137(6):777-784.
  92. Nelson CA, Wewerka S, Thomas KM, Tribby-Walbridge S, deRegnier R, Georgieff M. Neurocognitive sequelae of infants of diabetic mothers. Behav Neurosci 2000 Oct;114(5):950-956.
  93. Reece EA, Homko CJ. Infant of the diabetic mother. Semin Perinatol 1994 Oct;18(5):459-469.
  94. Reece EA, Homko CJ. Why do diabetic women deliver malformed infants? Clin Obstet Gynecol 2000 Mar;43(1):32-45.
  95. Rizzo T, Metzger BE, Burns WJ, Burns K. Correlations between antepartum maternal metabolism and intelligence of offspring. N Engl J Med 1991 Sep;325(13):911-916.
  96. Rizzo TA, Metzger BE, Dooley SL, Cho NH. Early malnutrition and child neurobehavioral development: insights from the study of children of diabetic mothers. Child Dev 1997 Feb;68(1):26-38.
  97. Schwartz R, Teramo KA. Effects of diabetic pregnancy on the fetus and newborn. Semin Perinatol 2000 Apr;24(2):120-135.
  98. Vaarasmaki MS, Hartikainen A, Anttila M, Pramila S, Koivisto M. Factors predicting peri- and neonatal outcome in diabetic pregnancy. Early Hum Dev 2000 Jul;59(1):61-70.
  99. Robertson SS, Dierker LJ. Fetal cyclic motor activity in diabetic pregnancies: sensitivity to maternal blood glucose. Dev Psychobiol 2003 Jan;42(1):9-16.
  100. Accardo PJ, Blondis TA, Whitman BY. Disorders of attention and activity level in a referral population. Pediatrics 1990 Mar;85(3 Pt 2):426-431.
  101. Ornoy A, Uriel L, Tennenbaum A. Inattention, hyperactivity and speech delay at 2-4 years of age as a predictor for ADDADHD syndrome. Isr J Psychiatry Relat Sci 1993;30(3):155-163.
  102. Smyth TR. Impaired motor skill (clumsiness) in otherwise normal children: a review. Child Care Health Dev 1992 Sep-Oct;18(5):283-300.
  103. Petersen MB, Pedersen SA, Greisen G, Pedersen JF, Mølsted- Pedersen L. Early growth delay in diabetic pregnancy: relation to psychomotor development at age 4. Br Med J (Clin Res Ed) 1988 Feb;296(6622):598-600.
  104. Sells CJ, Robinson NM, Brown Z, Knopp RH. Long-term developmental follow-up of infants of diabetic mothers. J Pediatr 1994 Jul;125(1):S9-S17.
  105. Vladareanu R, Lebit D, Constantinescu S. Ultrasound assessment of fetal neurobehaviour in high risk pregnancies. DSJUOG 2012 Apr-Jun;6(2):132-147.
  106. Talic A, Kurjak A, Ahmed B, Stanojevic M, Predojevic M, Kadic AS, Di Renzo GC. The potential of 4D sonography in the assessment of fetal behavior in high-risk pregnancies. J Matern Fetal Neonatal Med 2011 Jul;24(7):948-954.
  107. Bekedam DJ, Visser GH, de Vries JJ, Prechtl HF. Motor behaviour in the growth retarded fetus. Early Hum Dev 1985 Nov;12(2):155-165.
  108. Cioni G, Prechtl HF. Preterm and early postterm motor behaviour in low-risk premature infants. Early Hum Dev 1990 Sep;23(3):159-191.
  109. Seme-Ciglenecki P. Predictive value of assessment of general movements for neurological development of highrisk preterm infants: comparative study. Croat Med J 2003 Dec;44(6):721-727.
  110. Abo-Yaqoub S, Kurjak A, Mohammed AB, Shadad A, Abdel-Maaboud M. The role of 4-D ultrasonography in prenatal assessment of fetal neurobehaviour and prediction of neurological outcome. J Matern Fetal Neonatal Med 2012 Mar;25(3):231-236.
  111. Athanasiadis AP, Mikos T, Tambakoudis GP, Theodoridis TD, Papastergiou M, Assimakopoulos E, Tarlatzis BC. Neurodevelopmental fetal assessment using KANET scoring system in low and high-risk pregnancies. J Matern Fetal Neonatal Med 2013 Mar;26(4):363-368.
  112. Fauser BC, Tarlatzis BC, Rebar RW, Legro RS, Balen AH, Lobo R, Carmina E, Chang J, Yildiz BO, Laven JS, et al. Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertil Steril 2012 Jan;97(1):28-38.e25
  113. Sirmans SM, Pate KA. Epidemiology, diagnosis and management of polycystic ovary syndrome. Clin Epidemiol 2014; 6:1-13.
  114. Fauser BC, Diedrich K, Bouchard P, Domínguez F, Matzuk M, Franks S, Hamamah S, Simón C, Devroey P, Ezcurra D, et al. Contemporary genetic technologies and female reproduction. Human Reproduction Update 2011 Nov;17(6):829-847.
  115. Balen A, Conway G, Kaltsas G. Polycystic ovary syndrome: the spectrum of the disorder in 1741 patients. Hum Reprod 1995 Aug;10(8):2107-2111.
  116. Azziz R, Sanchez L, Knochenhauer ES, Moran C, Lazenby J, Stephens KC, Taylor K, Boots LR. Androgen excess in women: experience with over 1000 consecutive patients. J Clin Endocrinol Metab 2004 Feb;89(2):453-462.
  117. Wild S, Pierpoint T, McKeigue P, Jacobs H. Cardiovascular disease in women with polycystic ovary syndrome at longterm follow-up: a retrospective cohort study. Clin Endocrinol (Oxf) 2000 May;52(5):595-600.
  118. Hollinrake E, Abreu A, Maifeld M, Van Voorhis BJ, Dokras A. Increased risk of depressive disorders in women with polycystic ovary syndrome. Fertil Steril 2007 Jun;87(6): 1369-1376.
  119. Zawadski JK, Dunaif A. Diagnostic criteria for polycystic ovary syndrome. In: Givens JHF, Merriman G, editors. The polycystic ovary syndrome. Cambridge, MA: Blackwell Scientific; 1992. p. 377-384.
  120. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004 Jan;81(1):19-25.
  121. Azziz R, Carmina E, DeWailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, et al. Position statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. J Clin Endocrinol Metab 2006 Nov;91(11):4237-4245.
  122. Lujan ME, Jarrett BY, Brooks ED, Reines JK, Peppin AK, Muhn N, Haider E, Pierson RA, Chizen DR. Updated ultrasound criteria for polycystic ovary syndrome: reliable thresholds for elevated follicle population and ovarian volume. Hum Reprod 2013 May;28(5):1361-1368.
  123. Badawy A, Elnashar A. Treatment options for polycystic ovary syndrome. Int J Womens Health 2011 Feb;3:25-35.
  124. ACOG Committee on Practice Bulletins—Gynecology. ACOG Practice Bulletin No 108: Polycystic ovary syndrome. Obstet Gynecol 2009 Oct;114(4):936-949.
  125. Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group Consensus on infertility treatment related to polycystic ovary syndrome. Fertil Steril 2008 Mar;89(3): 505-522.
  126. Balen AH. Ovulation induction in the management of anovulatory polycystic ovary syndrome. Mol Cell Endocrinol 2013 Jul;373(1-2):77-82.
  127. Berridge DL, Winter TC. Saline infusion sonohysterography: technique, indications, and imaging findings. J Ultrasound Med 2004 Jan;23(1):97-112.
  128. Allison SJ, Horrow MM, Kim HY, Lev-Toaff AS. Salineinfused sonohysterography: tips for achieving greater success. Radiographics 2011 Nov-Dec;31(7):1991-2004.
  129. O'Neill MJ. Sonohysterography. Radiol Clin North Am 2003 Jul;41(4):781-797.
  130. Bonnamy L, Marret H, Perrotin F, Body G, Berger C, Lansac J. Sonohysterography: a prospective survey of results and complications in 81 patients. Eur J Obstet Gynecol Reprod Biol 2002 Apr;102(1):42-47.
  131. Lindheim SR, Adsuar N, Kushner DM, Pritts EA, Olive DL. Sonohysterography: a valuable tool in evaluating the female pelvis. Obstet Gynecol Surv 2003 Nov;58(11):770-784.
  132. Lindheim SR, Sprague C, Winter TC. Hysterosalpingography and sonohysterography: lessons in technique. AJR Am J Roentgenol 2006 Jan;186(1):24-29.
  133. Jeanty P, Besnard S, Arnold A, Turner C, Crum P. Air-contrast sonohysterography as a first step assessment of tubal patency. J Ultrasound Med 2000 Aug;19(8):519-527.
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