Indian Journal of Medical Biochemistry

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VOLUME 23 , ISSUE 1 ( January-April, 2019 ) > List of Articles

Original Article

Evaluation of Therapeutic Efficacy of Antioxidants in Psoriatic Cases

M Madhulatha, Vijayabhaskar M

Keywords : Antioxidants, MDA, Oxidative stress, Psoriasis, Total antioxidant capacity

Citation Information : Madhulatha M, M V. Evaluation of Therapeutic Efficacy of Antioxidants in Psoriatic Cases. Indian J Med Biochem 2019; 23 (1):167-169.

DOI: 10.5005/jp-journals-10054-0077

License: CC BY-NC 4.0

Published Online: 01-04-2019

Copyright Statement:  Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Introduction: Psoriasis is one of the debilitating diseases of the skin of chronic inflammatory origin. Oxidative stress is considered as the culprit for the oxidant and antioxidant imbalance, resulting in psoriasis. Objectives: This study was undertaken to know the effects of oxidative stress in the origin and development of psoriasis and to evaluate the beneficial effect of antioxidant therapy in psoriatic patients along with conventional treatment. Materials and methods: Thirty-three patients of age group 20–60 years with chronic plaque psoriasis, from the outpatient department of Dermatology, Mamata General Hospital, Khammam, Telangana, India were considered for the study. Patients with a duration of disease from 6 months to 2 years were enrolled for the study. The severity of psoriasis was determined using the psoriasis area severity index (PASI). Informed consent from the patients and institutional ethical committee clearance were taken. Antioxidant therapy was given for 8 weeks along with conventional therapy. Malondialdehyde (MDA) and total antioxidant capacity were measured and compared before and after the therapy. Results: After antioxidant therapy for 8 weeks, it was observed that there was a significant decrease in mean serum levels of MDA and increased levels of total antioxidant capacity (TAC). Conclusion: The results revealed that antioxidant therapy along with conventional therapy of psoriasis is more beneficial in the treatment of psoriatic cases.


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