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VOLUME 23 , ISSUE 1 ( January-April, 2019 ) > List of Articles
Keywords : Homocysteine, MDA, Oxidative stress, Total antioxidant capacity, Vitiligo
Citation Information : Madhulatha M. Assessment of Serum Homocysteine and Oxidative Stress in Vitiligo Patients. Indian J Med Biochem 2019; 23 (1):170-173.
License: CC BY-NC 4.0
Published Online: 01-04-2019
Copyright Statement: Copyright © 2019; The Author(s).
Introduction: Vitiligo is a pigmentation disorder affecting about 1–2% of the population with a multifactorial etiology. This condition may be acquired or often an inheritable disorder with polygenic inheritance pattern and complex pathogenic behavior. Increased Serum homocysteine levels and oxidative stress resulting from oxidant–antioxidant imbalance may play a vital role in the pathogenesis of vitiligo. Objectives: The present study aims to evaluate the serum levels of homocysteine and serum malondialdehyde (MDA) and total antioxidant capacity (TAC) in vitiligo patients and also to study the role of the same in the pathogenesis of the disease. Materials and methods: The study group comprised of 32 vitiligo patients of 16–40 years age group, attending outpatient department (OPD) in the Dermatology department of Mamata General Hospital, Khammam, Telangana, India. Thirty-two healthy individuals of the corresponding age group were selected as controls (control group) from the patient's attendants and hospital staff. Approval was obtained from the Institutional Human Ethical Committee. Prior informed consent was obtained from the selected participants. Serum level of homocysteine was measured using Axis homocysteine enzyme immunoassay (EIA). The MDA was determined as thiobarbituric acid reactive substances (TBARS). The total antioxidant capacity was estimated using ferric reducing ability of plasma (FRAP) assay. Results: Mean serum levels of homocysteine and MDA were significantly increased, and TAC was decreased considerably in vitiligo cases compared to controls. Conclusion: In cases of vitiligo patients, along with routine screening for homocysteine and oxidative stress status, the usage of antioxidants and homocysteine lowering agents such as vitamin B6, B12, and folic acid may prove beneficial as therapeutic agents.
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