Indian Journal of Medical Biochemistry

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VOLUME 23 , ISSUE 2 ( May-August, 2019 ) > List of Articles

Original Article

Lipoprotein (a) and Atherogenic Index of Plasma are Indicators for Endothelial Dysfunction in Pregnancy-induced Hypertensive Women

Visala Sree Jammalamadaga, Siva Prasad Palem

Keywords : Atherogenic Index of Plasma, Eclampsia, Endothelial Dysfunction, Lipoprotein (a), Preeclampsia

Citation Information : Jammalamadaga VS, Palem SP. Lipoprotein (a) and Atherogenic Index of Plasma are Indicators for Endothelial Dysfunction in Pregnancy-induced Hypertensive Women. Indian J Med Biochem 2019; 23 (2):263-266.

DOI: 10.5005/jp-journals-10054-0100

License: CC BY-NC 4.0

Published Online: 01-08-2019

Copyright Statement:  Copyright © 2019; The Author(s).


Abstract

Introduction: PIH is one of the most common causes of both maternal and neonatal morbidity. Endothelial dysfunction (ED) is a classic hallmark for PE. The mechanisms involved in the induction of ED are poorly understood. The disorders in lipoprotein metabolism are one of the most important causes for ED. AIP is another risk factor calculated by log (triglyceride/HDL-c) which is an indicator of atherosclerosis. The role of Lp(a) in atherosclerosis and its ability to induce thrombosis makes it important in normal and complicated pregnancies. So, a study has been designed to analyse the levels of Lp(a), Atherogenic index of plasma (AIP), and Nitric oxide (NO) in PIH women. Materials & Methods: A cross-sectional analytical study involved normotensive, PE & E pregnant women with 100 subjects in each group. They were investigated for serum Lp(a), NO in the 3rd trimester of pregnancy. Lp(a) was estimated by commercial kit method, NO was measured by Griess method and AIP was calculated by standard formula log (triglyceride/HDL-c). Results: The systolic blood pressure (SBP), diastolic blood pressure (DBP), AIP were significantly high and NO levels were significantly low between 3 groups. The Lp(a) levels were significantly high in PE than controls. The Lp(a) and AIP were negatively correlated with NO. Conclusion: Lp(a) and AIP are indicators to predict endothelial dysfunction in preeclampsia and eclampsia subjects. AIP may be better predicable indicator than Lp(a), since it was significantly raised in both PE and E.


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  1. Maas AHEM, Van’t Hof AWJ, De Boer MJ. Cardiovascular risk in women after metabolic complications in pregnancy. Netherlands Heart J 2007;15(12): 415-417.
  2. Asghari, E., Faramarzi, M., & Mohammmadi, A. K. The Effect of Cognitive Behavioural Therapy on Anxiety, Depression and Stress in Women with Preeclampsia. Journal of Clinical and Diagnostic Research: JCDR 2016; 10(11): QC04.
  3. Shaheen, A., Khan, R. N., Fatima, S., Ali, R., Khan, I., & Khattak, S. Adipokine Serum visfatin level in pregnancy induced hypertension and uncomplicated pregnancy. Pak J Med Sci 2016; 32(6): 1419-1424.
  4. Jeyabalan, A. Epidemiology of preeclampsia: impact of obesity. Nutrition reviews 2013; 71(suppl 1): S18-S25.
  5. Agrawal, S., & Fledder Johann, J. Hypertensive disorders of pregnancy and risk of diabetes in Indian women: a cross-sectional study. BMJ open 2016; 6(8): e011000.
  6. Saxena, S., Srivastava, P. C., Thimmaraju, K. V., Mallick, A. K., Dalmia, K., & Das, B. Socio-demographic profile of pregnancy induced hypertension in a tertiary care centre. Sch J App Med Sci 2014; 2(6D): 3081-3086.
  7. Kintiraki E, Papakatsika S, Kotronis G, Goulis DG, Kotsis V. Pregnancy-induced hypertension: review. Hormones 2015;14(2):211-223.
  8. Hubel CA. Oxidative stress in the pathogenesis of preeclampsia. Proc Soc Exp Biol Med 1999;222(3):222-235
  9. Eleni Anastasiou, MD, John P Lekakis, MD, Maria Alevizaki, MD, PHD, Christos M Papamichael, MD, John Megas, MD, Athanasios Souvatzoglou, MD et al. Impaired endothelium-dependent vasodilatation in women with previous gestational diabetes. Diabetes Care 1998; 21(12): 2111-2115.
  10. Meenakshi S, Saikia pathak M & Paul A. A study on atherogenic indices of pregnancy induced hypertension patients as compared to normal pregnant women. JCDR 2015; 9(7): BC05-BC08.
  11. Dube JB, Boffa MB, Hegele RA, Koschinsky ML. Lipoprotein(a): more interesting than ever after 50 years. Curr Opin Lipidol 2012;23:133–40.
  12. Rey E, Kahn SR, David M, Shrier I. Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 2003; 361:901–908.
  13. Gifford R.W. Report of the national high blood pressure education program working group on high blood pressure in pregnancy. Am J Obstet Gynecol 2000;183(1):S1-S5.
  14. Isser, H. S., Puri, V. K., Narain, V. S., Saran, R. K., Dwivedi, S. K., & Singh, S. (2000). Lipoprotein (a) and lipid levels in young patients with myocardial infarction and their first- degree relatives. Indian heart Journal 2001; 53(4): 463-466.
  15. Oboh FO, Enobhayisobo EI. Effect of aqueous extract of Vernonia amygdalina leaves on plasma lipids of hyperlipidaemia adult male albino New Zealand rabbits. Afri Sci. 2009;10(4).
  16. Grove TH. Effect of reagent pH on determination of high-density lipoprotein cholesterol by precipitation with sodium phosphotungstate-magnesium. Clinical Chemistry. 1979 Apr 1;25(4):560-564.
  17. Sun J, Zhang X, Broderick M, Fein H. Measurement of nitric oxide production in biological systems by using griess reaction assay. Sensors. 2003 Aug 22;3(8):276-284.
  18. Schwartz RB. Preeclampsia-Eclampsia: Clinical and Neuro-radiographic correlates and insights into the pathogenesis of hypertensive encephalopathy. Radiology 2000; 217: 371-376.
  19. Johnson, Abbie Chapman, “Mechanisms of Seizure during Pregnancy and Preeclampsia”. graduate college dissertations and theses 2015; Paper 336.
  20. Cristina M. Sena, Ana M. Pereira, Raquel Seiça. Endothelial dysfunction — A major mediator of diabetic vascular disease. Biochimica et Biophysica Acta 2013; 1832 (12): 2216–2231.
  21. Tanmay Saha, et al. Role of nitric oxide, angiogenic growth factors and biochemical analysis in preeclampsia. Indian journal of biochemistry and biophysics 2013; 50: 462-466.
  22. Peramaiyan Rajendran, Thamaraiselvan Rengarajan, Jayakumar Thangavel, Yutaka Nishigaki, Dhanapal Sakthisekaran, Gautam Sethi, et al. The Vascular Endothelium and Human Diseases. Int J BiolSci 2013; 9(10):1057-1069.
  23. Sameer Ansar, Juraj Koska1 and Peter D Reaven. Postprandial hyperlipidemia, endothelial dysfunction and cardiovascular risk: focus on incretins. Cardiovascular Diabetology 2011;10:61
  24. Wittmaack, F M, Gåfvels, M E, Bronner, M, Matsuo, H, McCrae, K R, Tomaszewski, J E., ...& Strauss 3rd, J F Localization and regulation of the human very low density lipoprotein/apolipoprotein-E receptor: trophoblast expression predicts a role for the receptor in placental lipid transport. Endocrinology 1995; 136(1): 340-348.
  25. Winkler, K, Wetzka, B, Hoffmann, M M, Friedrich, I, Kinner, M, Baumstark, M W, ...& März, W Triglyceride-rich lipoproteins are associated with hypertension in preeclampsia. The Journal of Clinical Endocrinology & Metabolism 2003; 88(3): 1162- 1166.
  26. Angela E Fanshawe (MA, MBBS), Michael Ibrahim (MA, PhD), The current status of lipoprotein (a) in pregnancy: A literature review. Journal of Cardiology 2013; 61: 99–106.
  27. Wang, Y, Gu, Y, Zhang, Y, & Lewis, D F Evidence of endothelial dysfunction in preeclampsia: decreased endothelial nitric oxide synthase expression is associated with increased cell permeability in endothelial cells from preeclampsia. American journal of obstetrics and gynecology 2004; 190(3): 817-824.
  28. Bayhan, G, Koçyigit, Y, Atamer, A, Atamer, Y, & Akkus, Z Potential atherogenic roles of lipids, lipoprotein (a) and lipid peroxidation in preeclampsia. Gynecological endocrinology 2005; 21(1): 1.
  29. Nazli, R, Khan, M A, Akhtar, T, Lutfullah, G, Mohammad, N S, Ahmad, J, & Aslam, H Abnormal Lipid levels as a risk factor of eclampsia, study conducted in tertiary care Hospitals of Khyber Pakhtunkhwa Province-Pakistan. Pakistan journal of medical sciences 2013; 29(6): 1410.
  30. Fanshawe, A E, & Ibrahim, M The current status of lipoprotein (a) in pregnancy: A literature review. Journal of cardiology 2013; 61(2): 99-106.
  31. Cesur, M, Ozbalkan, Z, Temel, M A, & Karaarslan, Y Ethnicity may be a reason for lipid changes and high Lp (a) levels in rheumatoid arthritis. Clinical rheumatology 2007; 26(3): 355-361.
  32. Işildak, M Y, Yildirmak, S T, Doğan, S, Çakmak, M, & Özakin, E Serum Homocysteine and Lipoprotein (a) Levels in Preeclamptic Pregnants. Balkan Medical Journal 2009; 26(3): 208-213.
  33. Banerjee, D, Wong, E C, Shin, J, Fortmann, S P, & Palaniappan, L Racial and ethnic variation in lipoprotein (a) levels among Asian Indian and Chinese patients. Journal of lipids, 2011.
  34. Dobiasova, M AIP--atherogenic index of plasma as a significant predictor of cardiovascular risk: from research to practice. Vnitrni lekarstvi 2006; 52(1): 64-71.
  35. Aragon-Charris, J, Reyna-Villasmil, E, Guerra-Velasquez, M, Mejia-Montilla, J, Torres- Cepeda, D, Santos-Bolívar, J, & Reyna-Villasmil, N Atherogenic index of plasma in patients with preeclampsia and in healthy pregnant women. Medicina clinica 2014; 143(3): 104-108.
  36. Singh, M, Pathak, M S, & Paul, A A study on atherogenic indices of pregnancy induced hypertension patients as compared to normal pregnant women. Journal of clinical and diagnostic research JCDR 2015; 9(7): BC05.
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