Indian Journal of Medical Biochemistry

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VOLUME 23 , ISSUE 3 ( September-December, 2019 ) > List of Articles

Original Article

Association of Age and Ethnicity with Alcoholic Liver Diseases in East Sikkim

Samita Rai, Sonam C Bhutia, Sanjeev Dhakal, Mingma L Sherpa

Keywords : Alcoholic liver disease, Alkaline phosphatase, Ethnicity, Glutathione

Citation Information : Rai S, Bhutia SC, Dhakal S, Sherpa ML. Association of Age and Ethnicity with Alcoholic Liver Diseases in East Sikkim. Indian J Med Biochem 2019; 23 (3):309-311.

DOI: 10.5005/jp-journals-10054-0109

License: CC BY-NC 4.0

Published Online: 01-06-2018

Copyright Statement:  Copyright © 2019; The Author(s).


Background: Alcoholic liver disease (ALD) is most prevalent in Sikkim where its consumption is a common practice and accepted socially. Materials and methods: Fifty male patients and normal healthy groups were taken for the study. Direct and total bilirubin, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase (ALP), and reduced glutathione along with the relationship with age group and ethnicity were assessed. Results and conclusion: Biochemical parameters such as direct (1.6 ± 1.0) and total bilirubin (2.9 ± 1.5), aspartate aminotransferase (68.7 ± 1.629), alanine aminotransferase (29.8 ± 6.5), ALP (1.4 ± 3.4), gamma-glutamyl transferase (1.18 ± 8.4) were observed to be increased and oxidative stress markers like glutathione was decreased in patients with alcoholic liver disease. Highest number of patients with the disease were between 36 and 46 years (44%) of age and in Kiratis (40%). This is a first attempt to study the ALD based on age group and ethnicity. Various programs should initiated to prevent alcohol abuse.

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