Indian Journal of Medical Biochemistry

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VOLUME 21 , ISSUE 1 ( January-June, 2017 ) > List of Articles


Reliable Earlier and Causative Biomarker in newly Diagnosed Hypothyroid Cases—Vitamin D: A Case–control Study

AG Thivyah Prabha

Citation Information : Prabha AT. Reliable Earlier and Causative Biomarker in newly Diagnosed Hypothyroid Cases—Vitamin D: A Case–control Study. Indian J Med Biochem 2017; 21 (1):54-57.

DOI: 10.5005/jp-journals-10054-0020

License: CC BY 3.0

Published Online: 01-12-2012

Copyright Statement:  Copyright © 2017; The Author(s).



In Indian population there are 42 million people suffering from hypothyroidism. Hence, even though thyroid-stimulating hormone (TSH) has been used as the diagnostic marker of hypothyroidism, there arises a need to evaluate an earlier and a causative marker for hypothyroidism and thus it could be a better predictor of the disease in the earlier stages only.

Aims and objectives

The aim of the study is to identify a reliable earlier and one of the causative biomarkers of hypothyroidism.

Materials and methods

This study was conducted in 200 cases of newly diagnosed hypothyroidism and 200 controls of healthy individuals. Vitamin D, intact parathyroid hormone, TSH, triiodothyronine, thyroxine, and calcium were measured.


It was observed that vitamin D was significantly decreased in hypothyroid cases. There was a negative correlation between vitamin D and TSH.


Vitamin D being one of the causative factors in thyroid disorders should be included as a routine parameter of analysis in hypothyroid cases and supplementation of vitamin D also to be initiated by the clinicians to avoid the progression to overt hypothyroidism in the newly diagnosed cases.

How to cite this article

Prabha AGT. Reliable Earlier and Causative Biomarker in newly Diagnosed Hypothyroid Cases‗Vitamin D: A Case–control Study. Indian J Med Biochem 2017;21(1):54-57.

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