Indian journal of Medical Biochemistry

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VOLUME 25 , ISSUE 1 ( January-April, 2021 ) > List of Articles

Original Article

Differential Expression of SLC25A38 Gene in Patients of Acute Lymphoblastic Leukemia

Pritam Prakash, Santosh Kumar, Sanjay Kumar, Shraddha Raj, Poonam Sinha

Keywords : Acute lymphoblastic leukemia, Gene expression, Peripheral blood mononucleotide, Solute carrier 25A38

Citation Information : Prakash P, Kumar S, Kumar S, Raj S, Sinha P. Differential Expression of SLC25A38 Gene in Patients of Acute Lymphoblastic Leukemia. Indian J Med Biochem 2021; 25 (1):5-8.

DOI: 10.5005/jp-journals-10054-0168

License: CC BY-NC 4.0

Published Online: 00-04-2021

Copyright Statement:  Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

SLC25A38 gene produces a protein that belongs to the mitochondrial solute carrier family, SLC25. It is implicated in apoptotic pathways, which regulate intrinsic caspase-dependent apoptosis. The present study evaluates the expression of the SLC25A38 gene in acute lymphoblastic leukemia (ALL) patients. Among 30 leukemia patients, 25 were adult males and 5 were adult females. An average of 5.3-fold high expression of SLC25A38 gene among the ALL patients that was normalized to GAPDH relative to normal healthy volunteer was observed. There was a direct positive correlation between blast cell abundance and level of expression (r = 0.408, p = 0.025). The expression level was found to be associated with the proportion of blast cells in the bone marrow. The present results show that expression of SLC25A38 is a common feature in ALL and may be a novel biomarker for prognosis and diagnosis, as well as a potential therapeutic target for ALL.


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