Indian Journal of Medical Biochemistry

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VOLUME 28 , ISSUE 2 ( May-August, 2024 ) > List of Articles


A Correlation Study on Serum Biomarker and Biochemical Parameters in Acute Heart Failure with Duration of Hospital Stay among Patients with Acute Heart Failure

Suresh Shiva Kumar, Rangaswamy Ranga Raju, Mallikarjun Aradhya, Riyaz A Kalaburgi, Pavithra Venkateshaiah, Sathisha T Gururaja

Keywords : Acute heart failure, Duration of stay, In-patients, N-terminal pro-B-type natriuretic peptide, Prospective observational study

Citation Information : Kumar SS, Raju RR, Aradhya M, Kalaburgi RA, Venkateshaiah P, Gururaja ST. A Correlation Study on Serum Biomarker and Biochemical Parameters in Acute Heart Failure with Duration of Hospital Stay among Patients with Acute Heart Failure. Indian J Med Biochem 2024; 28 (2):41-44.

DOI: 10.5005/jp-journals-10054-0232

License: CC BY-NC 4.0

Published Online: 18-05-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Aims and background: Cardiac biomarker like serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) has revolutionized the diagnosis of heart failure and also plays an important role in prognosticating heart failure. Limited data exist in correlating the level of cardiac biomarkers and biochemical parameters with duration of hospital stay in patients with clinical evidence of acute heart failure. Materials and methods: Our study comprised of 200 inpatients diagnosed with acute heart failure both men and women using convenience sampling method. It is a prospective observational study. The inpatients were from the Department of Cardiology of Shridevi Institute of Medical Sciences and Research Hospital, Tumkur, Karnataka, India. The duration of study was from April 2022 to Sep 2023. Results: There was a positive correlation observed in serum NT-proBNP and potassium values with the duration of stay in the inpatients with acute heart failure (p < 0.05). Serum NT-proBNP was highly significant over a week stay at hospital with a median value of 4784 pg/mL (p < 0.05). Conclusion: The current study highlights the role of serum NT-proBNP and potassium ion as biomarker as well as prognostic factor in the morbidity of acute heart failure in patients. Clinical significance: The estimation of their serum levels may help in early prediction of duration of stay in hospital.

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  1. Sudharshana Murthy KA, Ashoka HG, Aparna AN. Evaluation and comparison of biomarkers in heart failure. Indian Heart J 2016;68(1): S22–S228. DOI: 10.1016/j.ihj.2015.09.003.
  2. Savarese G, Lund LH. Global public health burden of heart failure. Card Fail Rev 2017;3(1):7–11. DOI: 10.15420/cfr.2016:25:2.
  3. Satyamurthy I, Dalal JJ, Sawhney JP, et al. The Indian Consensus Document on cardiac biomarker. Indian Heart J 2014;66(1):73–82. DOI: 10.1016/j.ihj.2013.12.053.
  4. Zile MR, Claggett BL, Prescott MF, et al. Prognostic implications of changes in N-terminal pro-B-type natriuretic peptide in patients with heart failure. J Am Coll Cardiol 2016; 68(22):2425–2436. DOI: 10.1016/j.jacc.2016.09.931.
  5. Huffman MD, Prabhakaran D. Heart failure: Epidemiology and prevention in India. Natl Med J India 2010;23(5):283–288. PMID: 21250584.
  6. Green MD, Parker DM, Everett AD, et al. Cardiac biomarkers associated with hospital length of stay after paediatric congenital heart surgery. Ann Thorac Surg 2021;112(2):632–637. DOI: 10.1016/j.athoracsur.2020.06.059.
  7. Ky B, French B, Levy WC, et al. Multiple biomarkers for risk prediction in chronic heart failure. Circ Heart Fail 2012;5(2):183–190. DOI: 10.1161/CIRCHEARTFAILURE.111.965020.
  8. Krishna A, Kapoor A, Kumar S, et al. Elevated B-type natriuretic peptide levels in patients undergoing coronary stenting. J Invasive Cardiol 2011;23:240–245. PMID: 21646650.
  9. Leto L, Testa M, Feola M. The predictive value of plasma biomarkers in discharged heart failure patients: Role of plasma NT-proBNP. Minerva Cardioangiol 2016;64(2):157–164. PMID: 26373781.
  10. Harikrishnan S, Bahl A, Roy A, et al. Clinical profile and 90 day outcomes of 10 851 heart failure patients across India: National Heart Failure Registry. ESC Heart Fail 2022;9(6):3898–3908. DOI: 10.1002/ehf2.14096.
  11. Rørth R, Jhund PS, Yilmaz MB, et al. Comparison of BNP and NT-proBNP in patients with heart failure and reduced ejection fraction. Circ Heart Fail 2020;13(2):e006541. DOI: 10.1161/CIRCHEARTFAILURE.119.006541.
  12. IOM (Institute of Medicine). Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease. Micheel CM, Ball JR (Editors). Washington (DC): National Academies Press; 2013.
  13. Brown JR, Jacobs JP, Alam SS, et al. Utility of biomarkers to improve prediction of readmission or mortality after cardiac surgery. Ann Thoracic Surg 2018;106(5):1294–1301. DOI: 10.1016/j.athoracsur.2018.06.052.
  14. Januzzi JL, Peacock WF, Maisel AS, et al. Measurement of the interleukin family member ST2 in patients with acute dyspnea: Results from the PRIDE (Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department) study. J Am Coll Cardiol 2007;50(7):607–613. DOI: 10.1016/j.jacc.2007.05.014.
  15. Pascual-Figal DA, Ordoñez-Llanos J, Tornel PL, et al. Soluble ST2 for predicting sudden cardiac death in patients with chronic heart failure and left ventricular systolic dysfunction. J Am Coll Cardiol 2009;54(23):2174–2179. DOI: 10.1016/j.jacc.2009.07.041.
  16. Bayes-Genis A, de Antonio M, Galán A, et al. Combined use of high-sensitivity ST2 and NTproBNP to improve the prediction of death in heart failure. Eur J Heart Fail 2012;14(1):32–38. DOI: 10.1093/eurjhf/hfr156.
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