Indian Journal of Medical Biochemistry

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Volume  28 (2024)
Volume  27 (2023)
Volume  26 (2022)
Volume  25 (2021)
Volume  24 (2020)
Volume  23 (2019)
Volume  22 (2018)
Volume  21 (2017)
Volume  20 (2016)
Volume  19 (2015)
Related articles

VOLUME 28 , ISSUE 3 ( September-December, 2024 ) > List of Articles

ORIGINAL RESEARCH ARTICLE

Evaluation of Serum Ferritin Levels in Patients of Hypothyroidism

Vartika Saini, Sunny Chopra, Jaspinder Kaur, Maninder Kaur

Keywords : Enzyme linked Immunosorbent assay, Hypothyroid, Serum ferritin, Thyroid peroxidase, Thyroid-stimulating hormone, Thyroxine, Triiodothyronine

Citation Information : Saini V, Chopra S, Kaur J, Kaur M. Evaluation of Serum Ferritin Levels in Patients of Hypothyroidism. Indian J Med Biochem 2024; 28 (3):60-62.

DOI: 10.5005/jp-journals-10054-0239

License: CC BY-NC 4.0

Published Online: 19-08-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Abstract

Background: The thyroid gland is a bilobed endocrine gland that secretes two vital hormones: thyroxine (T4) and triiodothyronine (T3). The production and release of these hormones are regulated by the thyroid-stimulating hormone (TSH) from the pituitary gland. Iron is an essential element for the normal functioning of the thyroid gland. In the body, iron is stored in the form of ferritin, an intracellular protein. The aim of the present study was to evaluate the serum ferritin levels in patients with hypothyroidism. Materials and methods: This case-control study was conducted on 100 lab-diagnosed cases based on the thyroid profile. About 50 healthy controls were included in the study. Thyroid profile which includes estimation of serum T3, T4, and TSH was done. Serum ferritin levels were also estimated in both cases and controls. Results: The mean ± SD value of serum TSH levels in study group and control group was 14.45 ± 12.96 µIU/mL and 1.27 ± 1.05 µIU/mL, respectively. The mean ± SD of Serum ferritin in study group and control group was 9.95 ± 6.36 ng/mL and 149.35 ± 103.16 ng/mL, respectively. Serum ferritin and TSH shows significant (p-value ≤ 0.001). A significant negative correlation was found between TSH and serum ferritin in hypothyroid patients. Conclusion: This suggests that hypothyroid patients had higher levels of TSH and lower levels of serum ferritin compared to the control group, and that there is a negative correlation between TSH and serum ferritin in hypothyroid patients. Hence, the estimation of serum ferritin concentration among hypothyroid patients could be useful in the evaluation of thyroid hormone status.

PDF Share
  1. Sachdeva A, Singh V, Malik I, et al. Association between serum ferritin and thyroid hormone profile in hypothyroidism. Int J Med Sci Public Health 2015;(4):863–865. DOI: 10.5455/ijmsph.2015.24012015174.
  2. Michalakis KG, Mesen TB, Brayboy LM, et al. Subclinical elevations of thyroid-stimulating hormone and assisted reproductive technology outcomes. Fertil Steril 2011;(95):2634–2637. DOI: 10.1016/j.fertnstert.2011.02.056.
  3. Status of goitre or thyroid disorders in India. Ministry of health and family welfare:2022. Available from: https://pib.gov.in>PressRelease page.aspx?PRID=1796440.
  4. Nancy S, Pillai, Jemela B. Prevalence of hypothyroidism amongst pregnant women: A study done in rural set up. International journal of Reproduction, Contraception, Obstetrics and Gynecology 2018;7(4):1586–1591. DOI: 10.18203/2320-1770.ijrcog20181360.
  5. Takamatsu J, Majima M, Miki K, et al. Serum ferritin as a marker of thyroid hormone action on peripheral tissues. J Clin Endocrinol Metabol 1985;61(4):672–676. DOI: 10.1210/jcem-61-4-672.
  6. Unni Krishan AG, Menon UV. Thyroid disorders in India. An epidemiological perspective. Indian J Endocrinol Metab 2011;15 (Suppl 2):78–81. DOI: 10.4103/2230-8210.83329.
  7. Murray RK, DK Granner, PA Mayes, et al. The diversity of the endocrine system. In Harper's illustrated Biochemistry. 26th edition. 2003. pp. 434–455.
  8. Akhter S, Nahar ZU, Parvin S, et al. Thyroid status in patients with low serum ferritin levels. Bangladesh J Med Biochem 2012;5(1):5–11. Available from: https://imsear.searo.who.int/handle/12345 6789/167221.
  9. Kammal M, Abdrabo AA. Assessment of thyroid hormone levels in Sudanase females with iron deficiency. Sudan Med J 2014;50(2): 98–102. DOI: 10.12816/0015580.
  10. Carvalho DP, Dupuy C. Thyroid hormone biosynthesis and release. Mol cell Endocrinol 2017;(458):6–15. DOI: 10.1016/j.mce.2017.01. 038.
  11. Craig Jio, McClelland DBL, Ludlan CA. Blood Disorder. In: NA Boon, NR Colledgge, Br Walder, JAA Hunter (Eds). Davidson's Principles and Practice of Medicine, 20th edition. Churchill Livingstone Elsevier; Philadelphia: 2006. pp. 999–1064.
  12. Rushton DH, Barth JH. What is the evidence for gender differences in ferritin and haemoglobin. Crit Rev Oncol Hematol 2010;73(1):1–9. DOI: 10.1016/j.critrevonc.2009.03.010.
  13. Taylor PN, Albrecht D, Scholz A, et al. Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol 2018;14(5):301–316. DOI: 10.1038/nrendo.2018.18.
  14. Krishnamurthy HK, Reddy, S, Jayaraman V, et al. Preliminary. Association of serum ferritin levels and thyroid hormones. 2023;13(3):68–79. DOI: 10.4236/ojcd.2023.133007.
  15. Kumar A, Prasad SD. Evaluation of serum ferritin levels in patients of primary hypothyroidism at RIMS, Ranchi Jharkhand. Int J of science and Research 2017;6(9):657–658.
  16. Sarin M, Arora P, Mohapatra SC. Association between Serum Ferritin and thyroid profile in Radiologically proven patients with Goiter with thyroiditis. The Journal of Community Health Management 2017;4(2):50–52. DOI: 10.18231/2394-2738.
  17. Mahajan P, Kumar S, Badyal A. Serum ferritin levels and thyroid profile: Relationship in Hypothyroidism. Indian Journal of Research 2019;4(8):28–29. DOI: 10.36106/PARIPES.
  18. Kumar S, Keshari JR, Kumari R, et al. Relationship between iron profile and Thyroid profile in hypothyroid patients. National journal of laboratory Medicine 2022;11(1):1–3. DOI: 10.7860/NJLM/2022/48551.2556.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.